[50] When the attack is resolved, a characteristic glial scar is formed by astrocytes. Transduality is not simply nonduality, but additionally requires something like qualitative superiority or immunity to attacks bound to the duality in question. If as expected MS is an heterogeneous disease and the lesion development process would not be unique. Current research in neuropathology, neuroimmunology, neurobiology, and neuroimaging, The most accepted sequence of events is first NAWM appearance, then the so-called pre-active lesions, with activated microglia, and finally the BBB breakdown, which enables the entry of T-cells to the CNS. WebDimensional Travel: The Black Flash can easily travel to and from the Speed Force at will. For this reason, they consider themselves entitled to the sacrifice of other races - that other races must pay penance to them and that they should be honored to do so. WebTransduality is the state of being wherein an entity exists independently of, and qualitatively beyond, various dual systems, ranging from very specific, limited sets of dual distinctions to duality itself on a conceptual level. Editor/authors are masked to the peer review process and editorial decision-making of their own work and are not able to access this work in the online manuscript submission system. Several biomarkers for diagnosis, disease evolution and response to medication (current or expected) are under research. This resemblance is only aesthetic however, as the Maykrs are in fact malevolent and are even to an extent aligned with the forces of Hell. The underlying cause is currently unknown. -Google(Wikipedia, Web Sites) -Youtube(Blogs, Videos) Special Thanks to : All of Super Fanon which gave me inspiration to create this kind of Power. [114][115] In particular, it is known that B-cells of MS patients secrete an unknown toxin against oligodendrocytes[116], It has been reported several times that CSF of some MS patients can damage myelin in culture[117][118][119][120][121] and mice[122][123] and ceramides have been recently brought into the stage. WebA simulation is the imitation of the operation of a real-world process or system over time. Activation of macrophages and lymphocytes and their migration across the barrier may result in direct attacks on myelin sheaths within the central nervous system, leading to the characteristic demyelination event observed in MS.[59] After demyelination has occurred, the degraded myelin sheath components, such as myelin basic proteins and Myelin oligodendrocyte glycoproteins, are then used as identifying factors to facilitate further immune activity upon myelin sheaths. Gray VS Esdeath (Fairy Tail VS Akame ga Kill!) In any case, understanding lesion patterns can provide information about differences in disease between individuals and enable doctors to make more effective treatment decisions. They have used this technological superiority to subjugate and essentially vassalize 'lesser' civilizations, posing as their gods and offering technological enlightenment and the questionably accurate 'life after death' in return for other species' servitude. Type 3 (Plurality): Characters that exist in a nondual state regarding all dual systems within the scope of an entire level of reality and qualitatively superior or immune to the effects caused within it. It is possible the Maykrs wear these as a social adornment due to their long history with the people ofArgent D'Nur, since the narrow facial features and somewhat angled eye placement resemble theirs. [1][2], The Maykrs are an incredibly advanced civilization, with technological abilities far beyond both the people ofEarthandArgent D'Nur. Flash Villain(s)This character, team, or organization, is or was primarily an enemy of any or all of the various incarnations of the Flash. WebMultiple sclerosis is an inflammatory demyelinating disease of the CNS in which activated immune cells invade the central nervous system and cause inflammation, neurodegeneration, and tissue damage.The underlying cause is currently unknown. Variation of Cosmic Entity Physiology. So, for example, fire and water are not a duality. [45] It seems that neurodegeneration is produced by damaged mitochondria, which in turn comes from activated microglia.[46]. This includes a maw of sharp teeth, little subdermal fat tissue, four sets of yellow eyes, and an exposed cortex. Venous insufficiency: Some morphologically special medullar lesions (wedge-shaped) have also been linked to venous insufficiency. It came for Wally West to draw him back to the Speed Force, but instead took Linda Park, Wally's girlfriend, into the Speed Force. WebResearchGate is a network dedicated to science and research. The journal presents original contributions as well as a complete international abstracts section and other special departments to provide the most current source of information and references in pediatric surgery.The journal is based on the need to improve the surgical care of infants and children, not only through advances in physiology, [77] Some molecular biochemical models for relapses have been proposed. Electrokinesis: His body generates great amounts of electricity. If the 0 and 1 of binary systems can be considered a duality, a transdual characters fundamental existence might be definable as being in [43], Another development in this area is the finding that some lesions present mitochondrial defects that could distinguish types of lesions. [56], The BBB is composed of endothelial cells which line the blood vessel walls of the central nervous system. [4], Maykr interior environment in Urdak (note the integration of basalt-like rock formations and red trees). BBB infection: It has also been pointed out that some infectious agents with positive correlation to MS, specially. Related to Multiple Forms. WebPassword requirements: 6 to 30 characters long; ASCII characters only (characters found on a standard US keyboard); must contain at least 4 different symbols; Human endogenous retroviruses (HERVs) have been reported in MS for several years. WebAbout Our Coalition. Activated microglia in turn produces demyelination. The Black Flash fulfills the role of Death for those who possess super-speed, returning them to the source of their powers: the Speed Force. Research shows that views of nature have an impact on our psychology and physiology. The Flash Vol 2 #138(June, 1998). The duality of fire would be fire and not fire. AJOG's Editors have active research programs and, on occasion, publish work in the Journal. [83] Uric acid levels are lower during relapses.[84]. Given that MS lesions begin inside the NAWM areas, these areas are expected to be produced by the same underlying condition that produces the lesions, and therefore the ultimate MS underlying condition, whatever it is. It is the enzyme GDP-L-fucose synthase.[87][88]. Ilana Katz Sand et al. Thanks to the Rumble Ball, Tony Tony Chopper (One Piece) has developed a variety of different transformations, each with its own advantages and after training for 2 years, he only needs to eat one Rumble Ball to transform into his Monster Point form, having mastered it. ", These differences are noticeable only in early lesions[38] and the heterogeneity was controversial for some time because some research groups thought that these four patterns could be a consequence of the age of the lesions. [3] This iscatastrophic for the Maykr race since their race would eventuallylose their leader and possibly even go extinctif it weren't for the use of Argent Energy. [57], The BBB is compromised due to active recruitment of lymphocytes and monocytes and their migration across the barrier. Inducing the formation of tight junctions can restore BBB integrity and reduces its permeability, which can be used to reduce the damage caused by lymphocyte and monocyte migration across the barrier as restored integrity would restrict their movement. [44], In multiple sclerosis, inflammation, demyelination, and neurodegeneration are observed together. Multiple sclerosis is an inflammatory demyelinating disease of the CNS in which activated immune cells invade the central nervous system and cause inflammation, neurodegeneration, and tissue damage. [16] MS is active even during remission periods. WebGet 247 customer support help when you place a homework help service order with us. CSF from MS Patients Induces Mitochondrial Dysfunction in Unmyelinated Neuronal Cultures. OLAP is part of the broader category of business intelligence, which also encompasses relational databases, report writing and data mining. List of Supernatural Powers and Abilities. Beyond-Dimensional Existence Dimensionlessness Outerversal Outerversal Entity Physiology Outerversal Existence Xenodimensional The power to be an entity beyond all dimensionality. Furthermore, these characters exist beyond the classical states of contradiction-allowing logic on some level of existence. WebThe Maykrs are an advanced extra-dimensional race that hail from the realm of Urdak. This contrasts with data structures, which are concrete representations of WebThe power to be an entity beyond all dimensionality. Some modes require energy to maintain form. An Abnormal Periventricular Gradient in Magnetisation Transfer Ratio Occurs Early in Multiple Sclerosis. This marks the beginning of an autoimmune attack which destroys myelin in active lesions. Superpower Wiki is a FANDOM Anime Community. That is to say, for any statement A about them they are in a state that can't be described as A is true, A is false, A is simultanously true and false or A is neither true nor false. [22][23], It is believed that they may correlate with differences in disease type and prognosis, and perhaps with different responses to treatment. There are three phases for how an unknown underlying condition may cause damage in MS: Multiple sclerosis differs from other idiopathic inflammatory demyelinating diseases in its confluent subpial cortical lesions. While normally covered entirely in white and gold armor plating, the Maykrs are actually flesh, despite them generally being referred to as 'ethereal beings' by other civilizations. A duality refers to a logical duality for the purpose of this ability. Willow Rosenberg (Buffy the Vampire Slayer) alternating between. At the same time as the birth of Diana to Hippolyta, the Amazonian assassin Myrina gave birth to the daughter of Darkseid in secret, aided by Penelope and watched by the oracle Menalippe. Currently it is unknown what the primary cause of MS is; if MS is a heterogeneous disease, the lesion development process would not be unique. There are three clinical phenotypes: relapsing-remitting MS (RRMS), characterized by periods of neurological worsening following by remissions; secondary-progressive MS (SPMS), in which there is gradual progression of neurological dysfunction with fewer or no relapses; and primary-progressive MS (MS), in which neurological deterioration is observed from onset. Users' personality may change as well. They appear in active white matter lesions and in gray matter in SPMS. Then, it was an "empire" (i.e., a great power) long before it had an emperor. Though originally a biopsy was required to classify the lesions of a patient, since 2012 it is possible to classify them by a blood test[20] looking for antibodies against 7 lipids, three of which are cholesterol derivatives[21] Cholesterol crystals are believed to both impair myelin repair and aggravate inflammation. [74] Another protein involved is CXCL12,[75] which is found also in brain biopsies of inflammatory elements,[76] and which could be related to the behavior of CXCL13 under methylprednisolone therapy. Instead of intracranial venous problems he described extracranial blockages, and he stated that the location of those obstructions seemed to influence the clinical course of the disease. Increased expression of pro-inflammatory cell surface markers have been observed in NAWM and "initial" lesions, corresponding to a so-called loss of homeostatic microglial equilibrium. [57] This results in disruption of the BBB, causing an increase in barrier permeability due to the degradation of tight junctions which maintain barrier integrity. A more detailed evidence of a correlation between the place and type of venous malformations imaged and the reported symptoms of multiple sclerosis in the same patients was published in 2010. The underbanked represented 14% of U.S. households, or 18. Their existence is fully transcendent of all dimensional levels on a conceptual or existential level, normally being portrayed as entirely external abstractions that lie outside of the applications of spatiotemporal dimensionality as a constant defined by physics on any level, even compared to infinite or uncountably infinite dimensions, usually by perceiving them as akin to fiction or something similarly insignificant. [citation needed], According to one of the researchers involved in the original research, "Two patterns (I and II) showed close similarities to T-cell-mediated or T-cell plus antibody-mediated autoimmune encephalomyelitis, respectively. Several theories have been proposed to explain it. The ability to obtain powers in different forms and switch between powers and fighting technique. In-game codex entries suggests they may have done this to multiple civilizations across the entire galaxy, which may include Earth during ancient times, for millions of years. [19], Four different damage patterns have been identified in patient's brain tissues. In order to pass through, molecules must be taken in by transport proteins or an alteration in the BBB permeability must occur, such as interactions with associated adaptor proteins like ZO-1, ZO-2 and ZO-3. [54], MS lesions are driven mainly by T-cells. It later returned to try and take Wally again, freezing time except for those who possessed a connection to the Speed Force. Claws: His hands contains clawed, that he can use for stabbing and slashing in combat. Referring to MS, the physiology refers to the different processes that lead to the development of the lesions and the pathology refers to the condition associated with the lesions. It's possible, however, that the appearance of the Khan Maykr has been demonified, i.e., corrupted into a much more hideous form by the use of Argent Energy over the course of millennia to prevent her Transfigurationsince similar aesthetic degradation can be observed on corrupted humans (like the Possessed) and Argenta (like the Deags). Sub-power of Mode Manipulation. [81] The low level of uric acid found in people with MS is manifestedly causative rather than a tissue damage consequence in the white matter lesions,[82] but not in the grey matter lesions. In this months Editors Choice feature, the editors note that certain perioperative decision making in thoracic surgery revolves around surgical dogma. [70], Whether BBB dysfunction is the cause or the consequence of MS[71] is disputed, because activated T-Cells can cross a healthy BBB when they express adhesion proteins. List of Supernatural Powers and Abilities, The Great Evil Beast/The Great Darkness (, The Thought Robot/Cosmic Armor Superman (, Maria Ushiromiya; eventually via The Magic of Origin, Noospheric/infospheric/Narrative Beings (. Their shape is influenced by their activity[49]. Combination of Evolution and Super Form. Some authors propose a primary neurodegenerative factor. The eye can be considered as a living optical device.It is approximately spherical in shape, with its outer WebEpidemiology of Diabetes MellitusRelated Heart Failure. Pathophysiology is a convergence of pathology with physiology. These are called Normal Appearing White Matter (NAWM) and Normal Appearing Grey Matter (NAGM). This theory in part could also explain why some patients report amelioration under dietary treatment. The Maykr species is believed to be ancient, and they generally consider themselves to be gods and far beyond the lives of other species, whom they refer to only as 'mortals.' Not to be confused with Personal Customization. Switch into different powers and abilities. CCSVI: The term "chronic cerebrospinal venous insufficiency" was coined in 2008 by Paolo Zamboni, who described it in patients with multiple sclerosis. The Journal Some hypotheses about how the BBB is compromised revolve around the presence of compounds in the blood that could interact with vessels only in the NAWM areas. [12], The evolution of a preactive lesion is related to microglia reactivity. The original report[citation needed] suggests that there may be several types of MS with different immune causes, and that MS may be a family of several diseases. Not to be confused with Personal Customization. Due to experimentation by Team Rocket, Vee (Pokmon Adventures) could freely shift between its first three evolutions. [86] Historically, several theories about how these areas appear have been presented: The search for an auto-antigen has taken a long time, but at least there is one reported. Form Change/Swapping/Switching WebWe are an Open Access publisher and international conference Organizer. WebCosmic Entity Physiology/Cosmic Deity Physiology Cosmic Manipulation : Users can generate , shape , and manipulate cosmic energies to produce nearly any effect they desire. The Journal of the American Academy of Dermatology (JAAD), the official scientific publication of the American Academy of Dermatology (AAD), aims to satisfy the educational needs of the dermatology community.As the specialty's leading journal, JAAD features original, peer-reviewed articles emphasizing: Some modes may have a time limit and users may need training to extend time limit or gain full control. The Republic was not a nation-state in the modern sense, but a network of towns left to rule This great being is said to have either been "split" to form the Maykr race, or to have transferred his incalculable power into the vast structure known as Urdak which then birthed the Maykrs in perpetuity. The mission of Urology , the "Gold Journal," is to provide practical, timely, and relevant clinical and scientific information to physicians and researchers practicing the art of urology worldwide; to promote equity and diversity among authors, reviewers, and editors; to provide a platform for discussion of current ideas in urologic education, patient [17], Follicle-like aggregates in the meninges are formed only in secondary progressive MS.[18] and correlate with the degree of subpial cortical demyelination and brain atrophy, suggesting that they might contribute to cortical pathology in SPMS[18], These ectopic lymphoid follicles are composed mainly of EBV infected B-cells. This contrasts them with Abrahamic depictions of angels, who are agents of Heaven and are in opposition to the forces of Hell, but consistent with depictions of demons. A list of these boxes is presented here for your convenience. The once holy realm fell into chaos as the Khan Maykr died at the hands of the Slayer. It was reportedly seen before the deaths of Barry Allen and Johnny Quick; Max Mercury, having had several near-death experiences, also saw the Black Flash. Dante (DmC: Devil May Cry) can switch between angelic and demonic modes, gaining different weapons and powers. [131], Others propose an oligodendrocyte stress as primary dysfunction, which activates microglia creating the NAWM areas[132] and others propose a yet-unknown intrinsic CNS trigger induces the microglial activation and clustering, which they point out could be again axonal injury or oligodendrocyte stress. This was already indicated by previous studies that found a relatively high rate of false diagnoses of MS among patients with AQP4-IgG-positive neuromyelitis optica spectrum disorders or MOG encephalomyelitis. To summarize: Beyond-Dimensional Physiology is beyond the concept of all dimensionalities. This template will categorize articles that include it into the category "Flash Villains.". The Master Morpher (Power Rangers) allows Tommy Oliver to access his various Ranger powers. The Maykrs show little to no remorse regarding the billions of lives that are lost in the process of sustaining their civilization, and will stop at nothing to enable the complete consumption of entire planets for their own good. They are much different than merely zero-dimensional creatures; as rather than simply lacking dimensions at all (and thus are geometrically infinitesimal in every possible direction), they are conceptually superior to the concepts of dimensional physics. Omnipotence: As God, The Presence possesses infinite power. WebThe ability to obtain powers in different forms and switch between powers and fighting technique. The Maykrs are an exceptionally long-lived race, but they are not immortal. Follow Jamaican news online for free and stay informed on what's happening in the Caribbean Freely available at, Harnessing the clinical value of biomarkers in MS, International Journal of MS care, June 2012, Alireza Minagar and J Steven Alexander, Bloodbrain barrier disruption in multiple sclerosis. In that case, the mask would possibly make the Argenta more inclined to believe the Maykrs are gods, rather than aliens. Pathologist, Mechanical flow: Later the focus moved to softer hemodynamic abnormalities, which were showing precede changes in sub-cortical gray matter. [63], The damaged white matter is known as "Normal-appearing white matter" (NAWM) and is where lesions appear. [66] Breakdown is responsible for monocyte infiltration and inflammation in the brain. An unknown soluble factor (produced by CD8+ T-cells or CD20+ B-cells), creates a toxic environment that activates microglia. achieving normal concentrations) is therapeutic in MS by preventing BBB breakdown through inactivation of peroxynitrite. The latter hypothesis is further corroborated by a recent study that demonstrated significant differences in routine cerebrospinal fluid findings between patients with pattern I lesions and patients with non-pattern I lesions, including a lack of CSF-restricted oligoclonal bands, in most pattern II and III patients. Compared to normal endothelial cells, the cells lining the BBB are connected by occludin and claudin which form tight junctions in order to create a barrier to keep out larger molecules such as proteins. In order to secure a supply of Argent Energy, the Maykrs has taken to invading other planets or dimensions to harvest the energy of other lifeforms. Then, it was an "empire" (i.e., a great power) long before it had an emperor. They are a hive-mind race, lead by the Khan Maykr. [61] MS has an important vascular component. The Khan Maykr, leader of the Maykr species, Story of Hell: Fuel the Eternal Flame - Part I. Peferoen, L., D. Vogel, Marjolein Breur, Wouter Gerritsen, C. Dijkstra, and S. Amor. [42] Finally, some previously diagnosed with pattern II MS were later found to have in fact MOG-IgG-related encephalomyelitis, suggesting that both the current clinicoradiological diagnostic criteria for MS and the histopathological criteria for MS may be insufficiently specific. And so they must obey a many-valued logic with at least 5 truth states, and not be in any of the 4 combinations of true and false mentioned earlier. Venous pathology has been associated with MS for more than a century. The Maykrs society is a form of hive-mind, with individuals that are more-or-less independent but obliged to always follow the will of their leader - theKhan Maykr. ", "Relapsing and Remitting Multiple Sclerosis: Pathology of the Newly Forming Lesion", "Pathophysiological processes in multiple sclerosis: focus on nuclear factor erythroid-2-related factor 2 and emerging pathways", "Pattern II and pattern III MS are entities distinct from pattern I MS: evidence from cerebrospinal fluid analysis", "Antigen microarrays identify unique serum autoantibody signatures in clinical and pathologic subtypes of multiple sclerosis", "Mitochondrial defects in acute multiple sclerosis lesions", 10.1002/1531-8249(199909)46:3<296::AID-ANA4>3.0.CO;2-#, "Nuclear Receptor NR1H3 in Familial Multiple Sclerosis", "Primary Progressive Multiple Sclerosis: Putting Together the Puzzle", "Three-Dimensional Lesion Phenotyping and Physiologic Characterization Inform Remyelination Ability in Multiple Sclerosis", "Inside-Out versus Outside-In models for virus induced demyelination: axonal damage triggering demyelination", "Loss of 'homeostatic' microglia and patterns of their activation in active multiple sclerosis", "The pathogenesis of lesions and normal-appearing white matter changes in multiple sclerosis: a serial diffusion MRI study", "Identification of an essential endogenous regulator of bloodbrain barrier integrity, and its pathological and therapeutic implications", "Elevated matrix metalloproteinase-9 and degradation of perineuronal nets in cerebrocortical multiple sclerosis plaques", "Population-Wide Principal Component-Based Quantification of Blood-Brain-Barrier Dynamics in Multiple Sclerosis", "Permeation of blood-borne IL15 across the bloodbrain barrier and the effect of LPS", "Tissue-type plasminogen activator is a regulator of monocyte diapedesis through the brain endothelial barrier", "Monocyte migration and LFA-1 mediated attachment to brain microvascular endothelia is regulated by SDF-1 through Lyn kinase", "Magnetic resonance imaging of human brain macrophage infiltration", "Biomarkers indicative of bloodbrain barrier disruption in multiple sclerosis", "Adhesion molecules in multiple sclerosis: relation to subtypes of disease and methylprednisolone therapy", New Therapeutic Target For Treatment Of Multiple Sclerosis, Jan. 2008, "Pathological Expression of CXCL12 at the Blood-Brain Barrier Correlates with Severity of Multiple Sclerosis", "Imaging correlates of leukocyte accumulation and CXCR4/CXCR12 in multiple sclerosis", "Impact of methylprednisolone treatment on the expression of macrophage inflammatory protein 3alpha and B lymphocyte chemoattractant in serum of multiple sclerosis patients", "The peroxynitrite scavenger uric acid prevents inflammatory cell invasion into the central nervous system in experimental allergic encephalomyelitis through maintenance of blood-central nervous system barrier integrity", "The bloodbrain barrier in cortical multiple sclerosis lesions", "White Matter Hemodynamic Abnormalities precede Sub-cortical Gray Matter Changes in Multiple Sclerosis", University of Zurich(2018, October 11). Clinical trials show the prevalence of heart failure in diabetic patients to range from 19% to 26%. Though autoimmune demyelination is strong, axons are preserved, showing that the standard model of a primary demyelination cannot be hold. WebFandom Apps Take your favorite fandoms with you and never miss a beat. S164-S164. [12], Most MS findings take place inside the white matter, and lesions appear mainly in a periventricular distribution (clustered around the ventricles of the brain). Dante (Devil May Cry series) can switch between four different Styles in combat: Deoxys (Pokmon) possesses four different forms that he can utilize and transform into; from left to right, Attack, Normal, Defense, and Speed. It has been found recently that B-cells are also involved. [55], The bloodbrain barrier (BBB) is a protective barrier that denies the entrance of foreign material into the nervous system. Clinical applications of the book's anatomical and physiological information are set apart from the text in boxed inserts and often deal with aspects of pathophysiology. Advanced version of Pan-Dimensional Physiology. We will guide you on how to place your essay help, proofreading and editing your draft fixing the grammar, spelling, or formatting of your paper easily and cheaply. Ron Wagner This process, however, was compromised by the absence of the Father's essence, leaving the Maykrs fearful of losing their wisdom and faculties. For instance, all organisms are made up of cells that process hereditary information encoded in genes, which can be transmitted to future generations.Another major theme is evolution, which explains Dr. Samuel Haydenhave described the Maykrs as a dying race, and it's possible that they cannot reproduce at all, being completely dependent on Argent Energy in order to prolong the lifespans of already living Maykrs, or most especially from succumbing to Transfiguration. "Do stressed oligodendrocytes trigger microglia activation in pre-active MS lesions?." Current models can be divided into two categories: inside-out and outside-in. [68], Using iron nanoparticles, involvement of macrophages in BBB breakdown can be detected. WebOnline analytical processing, or OLAP (/ o l p /), is an approach to answer multi-dimensional analytical (MDA) queries swiftly in computing. as doll form to be easily concealed and carried by an ally, while in this form, she retains her abilities and can still speak and move. -Superpower Fanon(Omnipotence, Omni Transcendence, Gestalt Monotheistic Deity Physiology, Meta Miracle Manipulation Pages). [39] Nevertheless, after some debate among research groups, the four patterns model is accepted and the exceptional case found by Prineas has been classified as NMO[40][41], For some investigation teams this means that MS is an immunopathogenetically heterogeneous disease. -Google(Wikipedia, Web Sites) -Youtube(Blogs, Videos) Special Thanks to : All of Super Fanon which gave me inspiration to create this kind of Power. Variation of Cosmic Entity Physiology. Naruto Uzumaki (Naruto) possesses a variety of different transformations/modes, such as. It is found in the gas state at room temperature. The human body: more than just a bag of bones. This process could only be done via the help ofthe Father's essence. Lucifer, for example, is described as being consumed with pride, and even to have the ability to appear as an "angel of light," and it is consistent with the Maykrs' sense of entitlement to rule other intelligent species and treat them like animals to be consumed. [51] Whatever the underlying condition for MS is, it appears that damage is triggered by an unknown soluble factor in the CSF, potentially produced in meningeal areas; this factor can diffuse into the cortical parenchyma and destroy myelin either directly or indirectly through microglia activation. Put another way, the Maykr are not unlike how Tolkien's Elves would be if they had turned toward evil. The lower section of the Maykrs, however, is split into several tendrils or tentacles. Connecting to nature in this way allows us to draw on geometric design patterns for inspiration. J. William Brown et al. Simulations require the use of models; the model represents the key characteristics or behaviors of the selected system or process, whereas the simulation represents the evolution of the model over time.Often, computers are used to execute the simulation. If the existence of any of these subsets of MS is confirmed, the situation would be similar to what happened for Devic Disease and Aquaporin-4[citation needed]. While most of them are still under research, there are some of them already well stablished: Meningeal tertiary lymphoid-like structures, F. Quintana et al., Specific Serum Antibody Patterns Detected with Antigen Arrays Are Associated to the Development of MS in Pediatric Patients, Neurology, 2012. Maykr technology is complex, sophisticated and generally very refined. Some modes may become corrupt and may have to be given up or fixed. Some clinical trials have shown that the inflammation produces both the relapses and the demyelination, and that neurodegeneration (axonal transection) is independent from inflammation, produces the accumulative disability, and advances even when inflammation and demyelination are delayed. What remained of the Father is his essence that resided in a temple-like building, the Luminarium, where Maykrs would go to seek answers.[1]. They first appeared in Doom Eternal. Fertility and Sterility is an international journal for obstetricians, gynecologists, reproductive endocrinologists, urologists, basic scientists and others who treat and investigate problems of infertility and human reproductive disorders. This includes buildings, weaponry and their armor. Likewise, natural elements and even representations of them using Biomorphic Forms & Patterns create spaces that are comfortable [and] captivating 1. 3 Quotations by or about Grail (Prime Earth), She was first mentioned, although unnamed, in. Associations. 111 RIVER ST, HOBOKEN 07030-5774, NJ USA: WILEY-BLACKWELL, 2013. inflammatory demyelinating disease of the CNS, idiopathic inflammatory demyelinating diseases, chronic cerebro-spinal venous insufficiency, "Perivenous demyelination: association with clinically defined acute disseminated encephalomyelitis and comparison with pathologically confirmed multiple sclerosis", "Pathogenic Mechanisms Associated With Different Clinical Courses of Multiple Sclerosis", "Alpha-B-Crystallin Induces an Immune-Regulatory and Antiviral Microglial Response in Preactive Multiple Sclerosis Lesions", "Identifying the Start of Multiple Sclerosis Injury: A Serial DTI Study", "A serial study of new MS lesions and the white matter from which they arise", "The immunopathology of multiple sclerosis: an overview", "MR Spectroscopy Indicates Diffuse Multiple Sclerosis Activity During Remission", "Novel mechanisms of chronic inflammation in secondary progressive multiple sclerosis", "Dysregulated Epstein-Barr virus infection in the multiple sclerosis brain", "Defective cholesterol clearance limits remyelination in the aged central nervous system", "Distinct patterns of multiple sclerosis pathology indicates heterogeneity on pathogenesis", "Part 1B Pathology: Lecture 11 - The Complement System", "A quantitative analysis of oligodendrocytes in multiple sclerosis lesions - A study of 113 cases", "Humoral pattern II multiple sclerosis pathology not associated with neuromyelitis Optica IgG", "Some MS patients have "Dramatic" responses to Plasma Exchange", "Potassium Channel KIR4.1 as an Immune Target in Multiple Sclerosis", "Anoctamin 2 identified as an autoimmune target in multiple sclerosis", "Histopathology and clinical course of MOG-antibody-associated encephalomyelitis", "Central role of Th2/Tc2 lymphocytes in pattern II multiple sclerosis lesions", "Sequencing the immunopathologic heterogeneity in multiple sclerosis", "Relapsing and remitting multiple sclerosis: pathology of the newly forming lesion", "Lesion genesis in a subset of patients with multiple sclerosis: A role for innate immunity? At some point, the essence of the Father was stolen by one of the Maykrs' member known as the Seraphim for unknown purposes and its whereabouts were never recovered. Several types of damage appear in the brain: normal appearing white matter (NAWM) and characteristic lesions. The Stranger is a cosmic entity that typically shows up alongside heavy hitters like Eternity, Galactus, Lord Chaos, and Master Order when major events are occurring in the universe. Through his own will, he defined every variable physical law of the universe, stating everything happens because he makes it happen. The Doom Slayer's disruption of the invasion forced the Khan Maykr to awaken the Icon of Sin to continue consuming the human race. In the air, carbon dioxide is transparent to visible light but absorbs infrared radiation, acting as a greenhouse gas.It is a trace gas in Earth's Multiple sclerosis can be pathologically defined as the presence of distributed glial scars (or sclerosis) in the central nervous system disseminated in time (DIT) and space (DIS). Quotations by or about Black Flash (New Earth), 15 Appearances of Black Flash (New Earth), 10 Images featuring Black Flash (New Earth), Character Gallery: Black Flash (New Earth), It should not be confused with the other personifications of death in the DCU: The. [124] Whatever the problem is, it produces apoptosis of neurons respecting astrocytes[125], In 2012 it was reported that a subset of MS patients have a seropositive anti-Kir4.1 status,[126] which can represent up to a 47% of the MS cases, and the study has been reproduced by at least two other groups. WebBreaking news from the premier Jamaican newspaper, the Jamaica Observer. MS could be considered a heterogeneous condition or a new medical entity will be defined for these cases. [78], Normally, gadolinium enhancement is used to show BBB disruption on MRIs. [64], BBB can be broken centripetally (the most normal) or centrifugally. Grail the Godkiller. The "Demons" (Witch Creek Road) are creature from outside of existence. WebDimensional Entity Physiology; Doppelgnger Physiology; Draconic Abomination; Fanon:Dualis Physiology; E Earth-Bound Physiology; Eldritch Physiology; Elemental Energy Physiology; Elemental-Digital Physiology; Emotional Energy Physiology; Empowered Mortal Physiology; Energy Enhanced Physiology; Energy Absorption: Black Flash's physiology allows him to absorb Speed Force energy to empower himself. Further activation of cytokines is also induced by macrophage and lymphocyte activity, promoting inflammatory activity as well continued activation of proteins such as matrix metalloproteinases, which have detrimental effect on BBB integrity. Book review", "Chronic cerebrospinal venous insufficiency in patients with multiple sclerosis", "Chronic cerebrospinal venous insufficiency and multiple sclerosis", "Intracranial venous haemodynamics in multiple sclerosis", "Embryological background of truncular venous malformation in the extracranial venous pathways as the cause of chronic cerebro spinal venous insufficiency", "Transfer of multiple sclerosis into severe combined immunodeficiency mice by mononuclear cells from cerebrospinal fluid of the patients", "Cerebrospinal fluid ceramides from patients with multiple sclerosis impair neuronal bioenergetics", "Potassium channel KIR4.1 as an immune target in multiple sclerosis", "Autoantibodies to Potassium Channel KIR4.1 in Multiple Sclerosis", "Imaging Surrogates of Disease Activity in Neuromyelitis Optica Allow Distinction from Multiple Sclerosis", "Clusters of activated microglia in normal-appearing white matter show signs of innate immune activation", "A gradient in cortical pathology in multiple sclerosis by in vivo quantitative 7 T imaging", "The intrathecal, polyspecific antiviral immune response in neurosarcoidosis, acute disseminated encephalomyelitis and autoimmune encephalitis compared to multiple sclerosis in a tertiary hospital cohort", "kFLC Index: a novel approach in early diagnosis of Multiple Sclerosis", Lesional demyelinations of the central nervous system, Experimental autoimmune encephalomyelitis, Leukoencephalopathy with vanishing white matter, Megalencephalic leukoencephalopathy with subcortical cysts, https://en.wikipedia.org/w/index.php?title=Pathophysiology_of_multiple_sclerosis&oldid=1125097228, Wikipedia articles needing factual verification from September 2010, Articles with unsourced statements from May 2022, Articles with unsourced statements from October 2021, Articles containing potentially dated statements from 2010, All articles containing potentially dated statements, Articles with unsourced statements from October 2017, Creative Commons Attribution-ShareAlike License 3.0. 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