Lycopene has been studied for its potential to lower the risk of heart disease and may help prevent the development of prostate cancer (52, 53, 54). Functional mitochondria perturbation is related to fulminant hepatic failure. Regarding regulator of calcineurin 1 (RCAN1), lycopene reduced mitochondrial ROS and intracellular concentrations, NF-B activity, Nucling expression, while decreasing the respiration per mitochondrion, MMP and glycolytic activity in RCAN1-overexpressing cells. Zhang F., Fu Y., Zhou X., Pan W., Shi Y., Wang M., Zhang X., Qi D., Li L., Ma K., et al. Some reports suggest that the benefits of lycopene could be stronger when you get it from whole foods (33). Jhou B.-Y., Song T.-Y., Lee I., Hu M.-L., Yang N.-C. Lycopene inhibits metastasis of human liver adenocarcinoma SK-Hep-1 cells by downregulation of NADPH oxidase 4 protein expression. Photo. Wang X., Yang H.-H., Liu Y., Zhou Q., Chen Z.-H. Lycopene consumption and risk of colorectal cancer: A meta-analysis of observational studies. The absorbed lycopene is mostly stored in the liver, adrenals, and prostate. Soleymaninejad M., Joursaraei S.G., Feizi F., Jafari Anarkooli I. Oh hi! Hedayati N., Naeini M.B., Nezami A., Hosseinzadeh H., Wallace Hayes A., Hosseini S., Imenshahidi M., Karimi G. Protective effect of lycopene against chemical and natural toxins: A review. * Additionally, lycopene has been shown to support vision in aging adults5so you can add this carotenoid to your longevity toolbox! Plant-derived bioactives in oral mucosal lesions: A key emphasis to curcumin, lycopene, chamomile, aloe vera, green tea and coffee properties. They can serve as a great post-workout snack, a side dish (sweet potato fries all day, please), or added to a coconut curry dish. Suppression of inducible nitric oxide synthase and tumor necrosis factor-alpha level by lycopene is comparable to methylprednisolone in acute pancreatitis. Additionally, it does not result in noticeable damage to the cell membrane, necrosis and regular apoptosis [46,47]. Lycopene is a type of organic pigment called a carotenoid. Lycopene administration also down-regulated the osteoclast differentiation along with up-regulation of the osteoblast and GPx CAT and SOD activities [77,141]. Lycopene and chemotherapy toxicity, Nutrition and Cancer, US National Library of Medicine, National Institutes of Health. It fights free radicals that may damage the DNA and other fragile cell structures. A cup and a half of watermelon contains nine to 13 milligrams of lycopene. Use left and right arrow keys to navigate between menu items. Lycopene is an antioxidant that has been linked to improving blood pressure and cardiovascular health, reducing cholesterol, and fighting a variety of cancers, says Laura Iu, RDN, CDN, CNSC, RYT, a registered dietitian and founder of Laura Iu Nutrition. On the other hand, AKT/mTORC2 overexpression decreases the lycopene impact on the FOXO3a expression and AKT phosphorylation, indicating the link between lycopene and the mTORC2/AKT signaling negative modulation [82]. Lin J., Li H.-X., Xia J., Li X.-N., Jiang X.-Q., Zhu S.-Y., Ge J., Li J.-L. Agarwal S., Rao A. Carotenoids and chronic diseases. Zeng Y.-C., Peng L.-S., Zou L., Huang S.-F., Xie Y., Mu G.-P., Zeng X.-H., Zhou X.-L., Zeng Y.-C. Lycopene and male infertility, Asian Journal of Andrology, US National Library of Medicine, National Institutes of Health. Patients dealing with the eye disease were found to have low serum levels of lycopene (13). Peng S., Li J., Zhou Y., Tuo M., Qin X., Yu Q., Cheng H., Li Y. Chen W., Mao L., Xing H., Xu L., Fu X., Huang L., Huang D., Pu Z., Li Q. Lycopene attenuates A1-42 secretion and its toxicity in human cell and. Lycopene was found to boost sperm count by as much as 70%. Lindshield B.L., Canene-Adams K., Erdman J.W., Jr. Lycopenoids: Are lycopene metabolites bioactive? So even if you cant grab fresh produce, other options may offer higher sources of lycopene than you think. As it turns out, researchers have found that lycopene and beta-carotene are the main carotenoids (aka antioxidants) found in both skin and plasma, which explains why they're often used in skin care products. Uar S., Pandir D. Furan induced ovarian damage in non-diabetic and diabetic rats and cellular protective role of lycopene. Since lycopene battles oxidative stress, it may help prevent long-term vision issues (14). Furthermore, second to astaxanthin (amongst different carotenoids), lycopene is the most potent antioxidant. In addition, it is a nutraceutical which protects against a wide variety of heart, liver, bone, skin, nervous, and reproductive systems diseases, as evident from numerous studies. The results indicate that the Nrf2/HO 1 signaling route is associated with lycopenes neuroprotective impact [133]. Increasing the amount of lycopene in the skin can protect the skin by preventing or reducing the damage caused by UV rays. Even the 99th percentile for its intake is 123 mg per day [156]. It can scavenge some of the potent oxidants that are known to be associated with atherosclerosis. https://pubmed.ncbi.nlm.nih.gov/11340098/, Things You Need to Know about Lecithin in Food Industries, The History and Benefits of Turmeric You Need to Know, How Does Lycopene Take Care of Your Skin, What You Need to Know About Lutein for Eyes. It can protect DNA, proteins, and lipids against oxidation. Trumbo P., Yates A.A., Schlicker S., Poos M. Dietary reference intakes: Vitamin A, vitamin K, arsenic, boron, chromium, copper, iodine, iron, manganese, molybdenum, nickel, silicon, vanadium, and zinc. Skin Health. This way, the antioxidant can help heal sunburn. Get it daily. It induces the release of certain detoxification proteins that help prevent prostate cancer (3). Another study showed the lycopene role via down-regulating the expression rate of the proprotein convertase subtilisin/kexin type-9 (PCSK-9) by inhibiting hepatocyte nuclear factor-1, improving LDL-receptor, and sterol regulatory element-binding protein-2. This is also an example of a food that can work well in an array of dishes, from a citrus salad or salmon marinate to smoothies and homemade popsicles. In gentamicin-induced nephrotoxicity, intake of lycopene and rosmarinic acid could reduce the elevated level of blood urea N2, serum creatinine, renal MDA and immune expression autophagic marker protein (LC3/B), proapoptotic protein (Bax), autophagic marker protein (LC3/B), iNOS and autophagic marker protein (LC3/B). Naviglio D., Sapio L., Langilla C., Ragone A., Illiano M., Naviglio S., Gallo M. Beneficial Effects and Perspective Strategies for Lycopene Food Enrichment: A Systematic Review. This review summarizes information regarding its sources and uses amongst different societies, its biochemistry aspects, and the potential utilization of lycopene and possible mechanisms involved in alleviating the abovementioned disorders. American Journal of Clinical Nutrition 96.5 (2012): n. pag. Brittany Loggins is a freelance writer covering health, wellness, and all things lifestyle. Bethesda, MD 20894, Web Policies It also decreased the migration of leukocytes in paw tissue and peritoneal cavity, lowered the concentration of MPO, while increasing the GSH levels [68]. Oxidative Medicine and Cellular Longevity 2016 (2016): 1-15. Thermal hyperalgesia is the perception of heat as pain, especially at abnormally high sensitivity (21). Interestingly, pretreatment with lycopene significantly reformed MDA and decreased GSH levels. Guava is a delicious tropical fruit with a yellow or light green skin and deep red or pink fresh. In addition, it is useful in the reduction in atherosclerotic plaque size, and arterial stiffness. Nine individuals were given tomato paste (16mg lycopene) and olive oil every day for 10 weeks while the control group of 10 people just consumed olive oil. A few studies claim the benefits of lycopene for exercise-induced asthma and benign prostatic hyperplasia ( 4 ). Lycopene is an antioxidant that can help to protect your skin from damage. Whole Food versus Supplement: Comparing the Clinical Evidence of Tomato Intake and Lycopene Supplementation on Cardiovascular Risk Factors, Advances in Nutrition, US National Library of Medicine, National Institutes of Health. Lycopene treatment against loss of bone mass, microarchitecture and strength in relation to regulatory mechanisms in a postmenopausal osteoporosis model, ScienceDirect. These studies conclude that dietary lycopene may protect the skin from long-term sun damage. But despite these findings, lycopene has limited ultraviolet protection and it is in no way a replacement for sunscreen or other traditional sun protection methods. At the beginning of the study and week 10, the subjects were exposed to a solar simulator and their skin redness was monitored. For example, an in vivo study revealed that lycopene (6.5 mg/day) was effective against cancer in men [147]. So by consuming foods with lycopene, we are helping fight off the free radicals and prevent further damage to healthy cells, Iu explains. It has potentantioxidant propertiesthat make it extremely beneficial for eye, brain, and heart health all while helping to protect your body from disease. I have short hair and don't always use gel. * For a high-quality, health-expert-vetted multivitamin that also provides a bouquet of antioxidant-rich botanicals (including carotenoids like lycopene), mbg's ultimate multivitamin+ addresses your daily nutritional needs (plus the added perk of longevity support) and then some. The antioxidant and anti-inflammatory properties of lycopene in mice lungs exposed to cigarette smoke. In addition, supplements containing lycopene and other natural antioxidants have been found to significantly improve skin texture. It also improved histopathological injury and repaired brain-derived neurotrophic factor (BDNF) amounts in mices hippocampal area. Moreover, ADR-induced histopathological changes were reversed by the lycopene treatment [143]. Lycopene in tomatoes: chemical and physical properties affected by food processing, Critical Reviews in Biotechnology, US National Library of Medicine, National Institutes of Health. It suppressed cell death, caspase-3 activation, DNA fragmentation, and cytochrome-c secretion in RCAN1-overexpressing cell lines [111]. Click here for additional information. Lycopene (50 mg/kg) significantly prevented AP by a substantial decrease in MPO activity, TNF- and down-regulating iNOS gene expression along with decreasing NO level, increasing pancreatic glutathione (GSH), decreasing serum -amylase and lipase functions in Wistar rats [64]. In addition, lycopene can act on other free radicals such as hydrogen peroxide, nitrogen dioxide and hydroxyl radicals [105]. PubMed. Baykalir B.G., Aksit D., Dogru M.S., Yay A.H., Aksit H., Seyrek K., Atessahin A. Lycopene ameliorates experimental colitis in rats via reducing apoptosis and oxidative stress. Treatment of human PCa cells was done with lycopene extracts (5 mg/mL) and indicated a significant drop in cell viability and apoptotic cell population [85]. The content is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Revised exposure assessment for lycopene as a food colour. Yin Y., Zheng Z., Jiang Z. Krinsky N.I., Beecher G., Burk R., Chan A., Erdman j.J., Jacob R., Jialal I., Kolonel L., Marshall J., Taylor Mayne P.R. In addition, lycopene decreased DNA damage [71]. Daily lycopene intake has been estimated as being significantly less than this level. You look like someone who loves free workouts, discounts for cutting-edge wellness brands, and exclusive Well+Good content. Gnc T., Ouz E., Sezen H., Koarslan S., Ouz H., Akal A., Adbelli F.M., akmak S., Aksoy N. Anti-inflammatory effect of lycopene on endotoxin-induced uveitis in rats. Other plant based sources of zinc include kidney beans, spinach, garbanzo beans, walnuts, cashews, and almonds. An official website of the United States government. Dos Santos R.C., Ombredane A.S., Souza J.M.T., Vasconcelos A.G., Plcido A., das GN Amorim A., Barbosa E.A., Lima F.C., Ropke C.D., Alves M.M. Lycopene is cancer-preventative phytonutrient. B-Carotene and Other Carotenoids in Protection from Sunlight." We write about products we think our readers will like. Moussa M., Landrier J.-F., Reboul E., Ghiringhelli O., Comra C., Collet X., Frhlich K., Bhm V., Borel P. Lycopene absorption in human intestinal cells and in mice involves scavenger receptor class B type I but not Niemann-Pick C1-like 1. 60-Second Cures for Common Holiday Stressors, Overindulged in Holiday Dishes? She has a diverse work experience as a Senior consultant for Government of India health projects in the more, Ravi Teja Tadimalla is an editor and a published author. Lycopene can be found in fresh or canned fruits and vegetables, as well as snacks that have been sun-driedthough it's worth noting any food that has had its skin and/or seeds removed will contain less lycopene. The .gov means its official. But even when you are taking lycopene through foods, you may want to keep a few things in mind. Holzapfel N.P., Holzapfel B.M., Champ S., Feldthusen J., Clements J., Hutmacher D.W. Ghadage S., Mane K., Agrawal R., Pawar V. Tomato lycopene: Potential health benefits. Tian Y., Xiao Y., Wang B., Sun C., Tang K., Sun F. Vitamin E and lycopene reduce coal burning fluorosis-induced spermatogenic cell apoptosis via oxidative stress-mediated JNK and ERK signaling pathways. Lycopene has anti-tumorigenic effects on paclitaxel and carboplatin. Ba H., Pandr D. Protective effects of lycopene on furantreated diabetic and non-diabetic rat lung. Woodside J.V., McGrath A.J., Lyner N., McKinley M.C. Lycopene has several molecular and cellular effects on human osteoblasts and osteoclasts. When it comes to food, lycopene is potent in a number of red- and pink-hued fruits and vegetables. We dont realize the [minimum] amount of dietary fat required for maximum carotenoid absorption. It may simply be some grams per meal though, wherein case an eighth of an avocado might fit the invoice, or just one or walnuts. A recent study found evidence that lycopene reduced bad cholesterol (LDL) Moreover, supplementation with lycopene reduced the STAT3 expression in ovarian tissues via the induction of the protein inhibitor of activated STAT3 expression [44,45]. Naturally, lycopene can be found in all the trans isomers, but the cis isomers are the most typical type in tissue and plasma [34]. Moussa M., Gouranton E., Gleize B., Yazidi C.E., Niot I., Besnard P., Borel P., Landrier J.F. Brittany is a graduate of the University of Georgia with a Bachelors degree in consumer journalismand you can still find her cheering on the Bulldogs every single chance she gets. You may take lycopene through supplements. The possible benefits of watermelon rind include better heart health, and even a better time in bed. One specific sign of Alzheimers is the accumulation of beta-amyloid plaques in the brain.One studyfound that lycopene helped to reduce oxidative damage associated with beta-amyloid plaque accumulation in the brain, making it a powerful brain protector. 2022Well+Good LLC. Li Y.F., Chang Y.Y., Huang H.C., Wu Y.C., Yang M.D., Chao P.M. Tomato juice supplementation in young women reduces inflammatory adipokine levels independently of body fat reduction. Table 1 shows its amount in different sources [23,24,25]. Like many antioxidants, lycopene could boost your heart health byreducing oxidative damageto your heart and arteries, and helping tolower cholesterol levelsin your blood.One particular studyfound that diets rich in lycopene were associated with a 17 to 26 percent lower risk of dying prematurely from heart disease and metabolic syndrome! Studies have found that this antioxidant can delay paralysis by correcting corrupted cells and protecting the healthy ones (9). Various mechanisms for lycopenes biological effects. Ateahin A., Trk G., Karahan I., Yilmaz S., Ceribai A.O., Bulmu O. Lycopene prevents adriamycin-induced testicular toxicity in rats. Lim S., Hwang S., Yu J.H., Lim J.W., Kim H. Lycopene inhibits regulator of calcineurin 1-mediated apoptosis by reducing oxidative stress and down-regulating Nucling in neuronal cells. will also be available for a limited time. It reduced HO-1 and IL-1 LPS-related expression in the hippocampus as well as reducing TNF- and IL-6 in the plasma [120,121]. Nevertheless, variation in lycopene consumption was reported, where adults in Spain consume less lycopene (1.64 mg/day) compared to adults from France, and the UK, where the intake was from 4.43 to 5.01 mg/day [27,28]. The administration of lycopene also decreased the level of ventricular remodeling post-MI [103]. All Rights Reserved. In the case of THP1 cells, lycopene (2 M for 2 h) strengthened pro-inflammatory gene expression. *, "High dietary intake of lycopene has been shown to be beneficial for cardiovascular health,"* explains registered dietitian Jess Cording, M.S., R.D., CDN. Lycopene may also treat priapism in males. Song B., Liu K., Gao Y., Zhao L., Fang H., Li Y., Pei L., Xu Y. Lycopene and risk of cardiovascular diseases: A meta-analysis of observational studies. Authority E.F.S. Long-term lycopene consumption is also linked with skin cancer prevention. While different types of carotenoids exist, lycopene is one form that gives certain fruits and veggies their vibrant red to light pink color in foods, such as red tomatoes and watermelon. Lycopene-rich products and dietary photoprotection, Photochemical & Photobiological Sciences, US National Library of Medicine, National Institutes of Health. Tomatoes are among the richest sources of lycopene. Lycopene decreases the fatty acid synthase (FAS), sterol regulatory element-binding protein 1c (SREBP-1c), and Acetyl-CoA carboxylase (ACC1) expression in HFD mice. Previous studies suggested its significant protection against a wide variety of natural and chemical toxins. Although there are currently no known risks or side effects of consuming lycopene from food, Iu suggests consulting with your healthcare provider before taking supplements and prioritizing a food-first regime to reap the many health benefits of lycopene. Theoretically, lycopene's ability to regulate cell-to-cell junctions might provide an additional benefit of improving skin texture. Lycopene noticeably improves the GFAP and Iba-1 expression as the glial cells inflammatory makers. Lycopene, when applied as a topical solution, protects against sunburn. Combining lycopene and exercise can also contribute to bone health (16). privacy policy, terms of use and CA privacy, All Hair Style's To Find Your Next Hot Look, Gajowik, Aneta, and Magorzata M. Dobrzyska. Lycopene not only quenches singlet ROS, but also prevents lipid peroxidation, too. This makes measurements to protect the skin to be essential.3. The antioxidant properties of lycopene may help boost sperm quality. Ardawi M.-S.M., Badawoud M.H., Hassan S.M., Rouzi A.A., Ardawi J.M., AlNosani N.M., Qari M.H., Mousa S.A. Lycopene treatment against loss of bone mass, microarchitecture and strength in relation to regulatory mechanisms in a postmenopausal osteoporosis model. Lycopene is a cardioprotective nutraceutical. It is an important deactivator of reactive oxygen species (ROS). Before The chemopreventive potential of lycopene against atrazine-induced cardiotoxicity: Modulation of ionic homeostasis. Hot shower; dry off; apply Paul Mitchell Conditioner to hair AND FACE; splash face with hot water; pre-shave sideburns, mouth area. Lycopene and metabolic syndrome: A systematic review of the literature. It can protect DNA, proteins, and lipids against oxidation. Lycopene consumption also regulated d-GalN/LPS-related disturbance in ATP synthesis and elevated enzymatic functions [123]. They combat inflammation, thereby preventing serious ailments like cancer and heart disease. Yogurt has soothing and nourishing effects. Lycopene also protects rats against acute lung injury due to LPS by reducing the IL-6 and TNF- level, suppressing MAPK activity and NF-B transcription factor. Liu C.-B., Wang R., Yi Y.-F., Gao Z., Chen Y.-Z. Getting more lycopene in your diet could, therefore, help prevent the onset of conditions like dementia. Clinical images, Canadian Medical Association Journal. Likewise, lycopene improved LPS-induced oxidative stress by increasing total antioxidant and HDL-related PON-1 function as well as down-regulating the plasma level and inflammatory mediators expression [107]. Although previous studies only give ideas about lycopene intake at a different level, that would be helpful. Photo Credit. What is lycopene? Figure 1 shows the molecular structures of lycopene and its derivatives and isomers. ATZ (50 and 200 mg/kg) induced hepatotoxicity, whereas lycopene (5 mg/kg) significantly reduced the total cytochrome b5 (Cyt b5) and CYP450 contents. Yogurt has a lot of benefits for the digestive system and skin health. -amyloid increased the serum IL-1, TNF-, IL-6 levels, and upregulated the expressions of NF-B p65 mRNA, TLR4 and protein at the choroid plexus. If you buy them, we get a small share of the revenue from the supplier. She spent time on staff at CBSNews.com and TODAY.com, where she wrote about everything from breaking news to the best scented candles. Furthermore, lycopene was studied for its positive health benefits on some important inflammatory factors (e.g., CRP, IL-6), lowering blood pressure, pulse wave velocity, adhesion molecules (ICAM-1) and endothelial function (flow-mediated dilation) [60]. Yu L., Wang W., Pang W., Xiao Z., Jiang Y., Hong Y. Dietary lycopene supplementation improves cognitive performances in tau transgenic mice expressing P301L mutation via inhibiting oxidative stress and tau hyperphosphorylation. The health benefits of lycopene have been well documented. By Dani Blum. Moreover, an increase in STAT3 motioning via adenovirus noticeably blocked a decrease in fasting blood insulin as well as glucose amount [94]. Inflammation is known as one of the most important key points in cancer. Potential inhibitory effect of lycopene on prostate cancer. Lycopene: Benefits, Side Effects, and Interactions - Verywell Health In addition, lycopene decreased testicular MDA concentration and increased GPx activity [144]. In another study on PCa, lycopene, or its metabolite (i.e., apo-10-lycopene), enhanced , -carotene-9, 10-oxygenase 2 (BCO2) expression, while decreasing cell proliferation in androgen-sensitive cells. In another study by Yefsah-Idres et al. Serum Lycopene Concentrations and Associations with Clinical Outcomes in a Cohort of Maternal-Infant Dyads, Harvard Library, Office for Scholarly Communication. A new study confirms that you dont have to do a hard workout to reap the longevity rewards of exercise. A small study of 19 healthy people found that lycopene could help to reduce the severity of sunburn. Tomatoes cooked in olive oil seem to have a much better bioavailability of lycopene (4). CD36 is involved in lycopene and lutein uptake by adipocytes and adipose tissue cultures. Tomato and tomato-based products are the major dietary sources of lycopene and account for approximately 80% of the consumption of lycopene in western countries. Furthermore, future directions with the possible use of this nutraceutical against lifestyle-related disorders are emphasized. Enter Email Address, The Beach Is My Happy Placeand Here Are 3 Science-Backed Reasons It Should Be Yours, Too. It can help protect DNA, proteins, and lipids from oxidation and promotes cellular resilience and longevity by scavenging free radicalsthus, promoting redox balance. National Institute of Public Health (2014): n. pag. Lu C.-W., Hung C.-F., Jean W.-H., Lin T.-Y., Huang S.-K., Wang S.-J. 3. Applying tomatoes is the easiest way to use lycopene for healing sunburn. Kaur H., Chauhan S., Sandhir R. Protective effect of lycopene on oxidative stress and cognitive decline in rotenone induced model of Parkinsons disease. On the other hand, oral administration of lycopene (10 mg/kg) to the rotenone-treated animals for 30 days elevated the activity by 39% compared to the animals treated with rotenone. Moreover, it can be found in other body parts (e.g., brain and skin) in a lower concentration [6]. Lycopene is a pigment with many antioxidant properties and health benefits. She received her bachelor's degree in Biological Basis of Behavior from the University of Pennsylvania and Ph.D. in Foods and Nutrition from the University of Georgia. Additionally, lycopene can effectively down-regulate APP expression in APPsw cells. Use tomato slices soaked in buttermilk to soothe discomfort caused by sunburn. In a study conducted on an animal model, in which male mice (C57BL/6) were orally administrated (lycopene dose; 10 or 100 mg/kg), the results reveal that lycopene significantly reduced ROS synthesis in SK-Hep-1 cells while inhibiting NADPH oxidase, which was carried by the protein kinase C (PKC) pathway. 3. The Potential Role of Lycopene for the Prevention and Therapy of Prostate Cancer: From Molecular Mechanisms to Clinical Evidence, International Journal of Molecular Sciences, US National Library of Medicine, National Institutes of Health. Tvrd E., Kovik A., Tuimov E., Pal D., Mackovich A., Alimov J., Luk N. Antioxidant efficiency of lycopene on oxidative stress-induced damage in bovine spermatozoa. [1]. Lycopene was also found to be effective against hepatotoxicity by acting as an antioxidant, regulating total glutathione (tGSH) and CAT concentrations, reducing glutathione disulfide (GSSG) and oxidative damage via reducing protein carbonylation. The lycopene present in tomatoes was found to guard the skin against cancer [5]. As well as this, it also decreased the improved JNK and also phosphorylation of the ERK [106]. Sheriff S.A., Devaki T. Lycopene stabilizes lipoprotein levels during D-galactosamine/lipopolysaccharide induced hepatitis in experimental rats. The tomato as a functional food. Heart disease is a major cause of death. Treatment with lycopene decreased UVB-caused cell proliferation while increasing apoptosis via declining CDK2 and CDK4 in hairless SKH-1 mice and human keratinocytes [82]. Lycopene protects plants from light-related stress and helps them use the energy of the sun to make nutrients. The site is secure. Chen P., Xu S., Qu J. Lycopene protects keratinocytes against UVB radiation-induced carcinogenesis via negative regulation of FOXO3a through the mTORC2/AKT signaling pathway. Lycopene (10 mg/kg BW, through 6 days) reduced lipid peroxidation and limited excessive H2O2 production. And in mbg's multi, our lycopene is extracted naturally and with care from red tomatoes (Lycopersicon esculentum). No significant differences were found in the bioavailability of cis- and trans-lycopene (24.5 vs. 23.2%, respectively). It is related to beta- carotene and gives some vegetables and fruits (e.g., tomatoes) a red color. In another study, lycopene administration (5, 10 mg/kg, oral) significantly decreased impairment in biochemical, behavioral, neuroinflammatory and neurochemical markers in rats with haloperidol-induced orofacial dyskinesia [75]. Chen D., Huang C., Chen Z. As we saw, lycopene is among the most potent antioxidants. Caseiro M., Ascenso A., Costa A., Creagh-Flynn J., Johnson M., Simes S. Lycopene in human health. For instance, a study conducted by Ross et al. The anti-proliferative and anti-metastatic impacts were complemented via ITGB1, MMP9, ITGA5, FAK, ILK and EMT markers down-regulated expression, decreasing the MAPK activity and inhibiting integrin 5 protein expression [50]. When consumed in food, lycopene is safe for everyone to eat. Eating excessive amounts of lycopene may lead to a condition called lycopenemia, which is orange or red skin discoloration. The condition itself is harmless and goes away by eating a lower lycopene diet. Is Lycopene bad for kidneys? Mechanisms of multiple neurotransmitters in the effects of Lycopene on brain injury induced by Hyperlipidemia, Lipids in Health and Disease, US National Library of Medicine, National Institutes of Health. Implicating the role of lycopene in restoration of mitochondrial enzymes and BDNF levels in -amyloid induced Alzheimers disease. In a study on methotrexate-induced liver injury (20 mg/kg), histopathologic examination of the rats showed that inflammatory cell infiltration, sinusoidal dilatation and congestion were improved significantly by lycopene consumption (10 mg/kg). Effect of lycopene on PDGFR-, IGF-IR-, and VEGFR-mediated signal pathways. Moreover, it was confirmed that post-absorptive trans-to-cis isomerization affects tissue and plasma isomeric profiles [43]. *, I can feel confident that Im getting what I need by taking this daily*, Cece, Lycopene has an extremely strong ability to scavenge free radicals. Lei X., Lei L., Zhang Z., Cheng Y. Neuroprotective effects of lycopene pretreatment on transient global cerebral ischemia-reperfusion in rats: The role of the Nrf2/HO-1 signaling pathway. WebAbout Our Coalition. FOXO3a siRNA transfection prevents lycopene-related elevation in cell apoptosis, cleaved PARP expression and BAX. He has been in the digital media field for over Dr.Varsha is an Ayurveda doctor with degree in the Indian system of medicine and MD in the field of Ayurveda What Are The Health Benefits Of Lycopene? Lycopene is cancer-preventative phytonutrient an antioxidant with a laundry list of amazing benefits. In short, lycopene is said to be good for preventing various health problems, and also promotes vision and skin health. [3] [1] Mirahmadi, M., Azimi-Hashemi, S., Saburi, E., Kamali, H., Pishbin, M. and Hadizadeh, F., 2020. Garlic There is a wide variety of pharmacological actions and clinical applications which have been attributed to the lycopene by a chain of researches worldwide. Higher utilization of fruits and vegetables, especially tomato-based products, may result in occasional intakes of 20 mg lycopene/day. Lycopene amends LPS induced oxidative stress and hypertriglyceridemia via modulating PCSK-9 expression and Apo-CIII mediated lipoprotein lipase activity. ); zk.ugmes@vokebmisseyz (Z.Y. Lycopene benefits the skin by helping it resist ultraviolet rays. Lycopene is a type of organic pigment called a carotenoid. The mutant (enzymatically inactive)/wild-type BCO2 exogenous expression in PCa cells decreased NF-B function, DNA binding and reduced NF-B translocation in the nucleus [89]. It was also found to downregulate inflammatory cytokines (i.e., TNF-, and IL-1) in the hippocampus of the mice. ), 9Department of Crop Science, College of Sanghuh Life Science, Konkuk University, Seoul 05029, Korea, 10Noncommunicable Diseases Research Center, Fasa University of Medical Sciences, Fasa 7461686688, Iran, 11Department of Persian Medicine, Fasa University of Medical Sciences, Fasa 7461686688, Iran, 12V.M. This site is for US consumers. Considering heart disease and cancer are the leading causes of death in the United States, integrating lycopene-rich foods can be one form of disease prevention. Yep. Zhou S., Zhang R., Bi T., Lu Y., Jiang L. Inhibitory effect of lycopene against the growth of human gastric cancer cells. The powerful antioxidant properties of lycopene fight free radicals and oxidative stress. Figure 2 illustrates some of the common signaling pathways which are mentioned in this section. Lets say that iron rusts in the air because of the loss caused by oxidation, and if left untreated, iron will soon corrode, and the bodys metabolism is like oxidation, which means that people are rusting every day, and this rust is medically known as free radicals. National Library of Medicine Sahni S., Hannan M.T., Blumberg J., Cupples L.A., Kiel D.P., Tucker K.L. It is important to note that lycopene promotes protection against skin damaging oxidation while contributing to upkeep the appearance of healthy skin. The antioxidant may also cut the risk of age-related macular degeneration. The authors declare no conflict of interest. Apply it as a pack and leave until dry (around 15 minutes). In nature, there are more than 600 carotenoids which are mostly colored, produced by plants, fungi and bacteria. Outer Color: Striped Green Flesh Color: Bright Yellow Taste: Similar to that of a red watermelon a subtle tinge of honey Seed color: Black Also available in seedless varieties Nutritional Information: Antioxidant beta carotene present If you are at the local grocery store searching for a wholesome, ripe yellow watermelon, Examples of antioxidants include vitamins C and E, selenium, and carotenoids, such as beta-carotene, lycopene, lutein, and zeaxanthin. Lycopene use (1 M) prior to the incidence of re-oxygenation significantly prevents hypoxia/reoxygenation (H/R)-induced cardiomyocyte death. Lycopene, as an antioxidant, helps to combat this free-radical damage and preserve your vision.One studyfound that lycopene helped reduce the effects of oxidative stress on lenses affected with cataracts, whileanother reviewsuggested that lycopene is an integral nutrient to incorporate in the prevention of age-related eye conditions. Safety monitoring should be considered as an important issue about medicinal plants and plant-derived phytochemicals [149,150]. To learn more, or opt-out, visit The effectiveness of lycopene dose is associated with using a pro-inflammatory stimulus (i.e., LPS, PMA or TNF). Lycopenes neuroprotective effect was also studied for pentylenetetrazol (PTZ)-induced kindling epilepsy in rats treated with lycopene at the concentrations of 2.5, 5, and 10 mg/kg, sodium valproate through 29 days, and 40 mg/kg of PTZ (intraperitoneal) with alternate days. Therefore, it must be consumed in a daily diet [5]. Lycopene is an anaerobic carotenoid and is a very powerful antioxidant. In another study, lycopene consumption markedly decreased the metastatic load in a tumor-bearing rat model of ovarian carcinoma. The interactions between advanced glycation end products (AGEs) and their receptors (RAGEs) induce oxidative stress-like conditions. 4 It is no These observations were more prominent in areas full of trabecular bone and low level of cortical bone. Therefore, it can be concluded that this nutraceutical has a vital role in the primary and secondary prevention of CVDs [3]. However, the results of several studies have been slightly inconsistent. Lycopene Supplements, Rogel Cancer Center, Michigan Medicine. In vitro effects and mechanisms of lycopene in MCF-7 human breast cancer cells. Regarding animal studies and epidemiological surveys, it can be used for both the prevention and treatment of diabetes [92]. Bioactive Compounds and Antioxidant Activity in Different Grafted Varieties of Bell Pepper, Antioxidants, US National Library of Medicine, National Institutes of Health. government site. Xia J., Lin J., Zhu S.Y., Du Z.H., Guo J.A., Han Z.X., Li J.L., Zhang Y. Lycopene protects against atrazine-induced hepatotoxicity through modifications of cytochrome P450 enzyme system in microsomes. There are many popular fruit juices available, with varying health benefits depending on the fruits they derive from. It also inhibited apoptosis in THG-treated cardiomyocytes [35,101,102]. Holzapfel N.P., Shokoohmand A., Wagner F., Landgraf M., Champ S., Holzapfel B.M., Clements J.A., Hutmacher D.W., Loessner D. Lycopene reduces ovarian tumor growth and intraperitoneal metastatic load. Salehi B., Lopez-Jornet P., Pons-Fuster Lpez E., Calina D., Sharifi-Rad M., Ramrez-Alarcn K., Forman K., Fernndez M., Martorell M., Setzer W.N. Keep reading. Enjoying a bowl of tomato soup may also benefit your eyes and skin. 1University Institute of Diet and Nutritional Sciences, Faculty of Allied Health Sciences, The University of Lahore, Lahore 54000, Pakistan; kp.ude.lou.csnd@8narmi.dammahum, 2Non-Communicable Diseases Research Center, Sabzevar University of Medical Sciences, Sabzevar 9617913112, Iran; ri.ca.smut.sunmula@tarohg-f, 3Department of Diet and Nutritional Sciences, Faculty of Health and Allied Sciences, Imperial College of Business Studies, Lahore 53720, Pakistan; kp.ude.lairepmi@sndd.doh, 4Department of Clinical Nutrition, NUR International University, Lahore 54000, Pakistan; kp.ude.uin@namher.bibah, 5Department of Food Science and Human Nutrition, University of Veterinary and Animal Sciences, Lahore Syed Abdul Qadir Jillani (Out Fall) Road, Lahore 54000, Pakistan; moc.liamg@3891noitirtundnadoof, 6Poostchi Ophthalmology Research Center, Shiraz University of Medical Sciences, Shiraz 7134845794, Iran; ri.ca.smus@iradyehm, 7Department of Technology of Food Products, K.G. The conversion of cis to trans isomerization takes place in enterocytes, liver and stomach [36,37]. Its consumption further inhibits biomarkers for ovarian cancer, such as CA125 expression. Lycopene is a carotenoid found in red, pink, and orange produceespecially red tomatoes. Sun radiation, air pollution, smoking, and pesticides in the external environment cause the body to produce more reactive oxygen radicals, which mutate nucleic acids, the root cause of human aging and disease. Lycopene is among the class of antioxidants that are known for their photoprotective properties. However, further investigations are necessary to unveil the underlying mechanisms of actions, with a special emphasis on gene expression studies. Lycopene considerably increased antioxidant enzymatic activity and decreased inflammatory cytokines in d-galactose-administrated mice serum. *, That's right, vitamin D and calcium shouldn't get all the credit for supporting your skeletal systemlycopene plays a role in bone health10 as well. Regarding AD, lycopene considerably prevents paralysis in A1-42-transgenic Caenorhabditis elegans strain GMC101. Additionally, the recommended and effective doses of this functional food need to be further investigated. Discovering the link between nutrition and skin aging, DermatoEndocrinology, US National Library of Medicine, National Institutes of Health. Lycopene is considered the most effective antioxidant out of the carotenoid family. As we get older, there are certain nutrients that we should incorporate more of in our diets. Moreover, tomato powder has been shown to have a protective agent against alcohol-induced hepatic injury by inducing cytochrome p450 2E1 [80]. Try adding in a few servings of these delicious foods each day, and you can be confident youre doing great things for your body. Moreover, it showed improved A-related mitochondrial morphological modifications, releasing cytochrome-c and opening of mitochondrial transition pores. Lycopene possesses potent anticancer, antioxidant, antiinflammatory, and antidiabetic potential. [2] https://pubmed.ncbi.nlm.nih.gov/11340098/. 1. Carini F., David S., Tomasello G., Mazzola M., Damiani P., Rappa F., Battaglia L., Cappello F., Jurjus A., Geagea A.G. Colorectal cancer: An update on the effects of lycopene on tumor progression and cell proliferation. Xanthophylls possess a minimum of an oxygenated group on their end rings, while unsaturated hydrocarbon carotenoids contain just carbon and hydrogen atoms with no oxygen [31]. 11 Feb. 2016, Gammone, Maria Alessandra, Graziano Riccioni, and Nicolantonio D'orazio. Lycopene is an antioxidant efficient in scavenging free radicals. There is scientific evidence which supports the beneficial role of lycopene against diabetes. In this article, learn about the different types, how to recognize the symptoms, and what treatment to expect. However, cell invasion, proliferation and migration showed no alteration in a dose-dependent fashion. In comparison, 11 types are conjugated double bonds, forming a chromophore involved in visible ruby color, as well as lycopene antioxidant activities [23]. However, it cannot regulate the NOS2 mRNA and COX-2 expression. Articles on StyleCraze are backed by verified information from peer-reviewed and academic research papers, reputed organizations, research institutions, and medical associations to ensure accuracy and relevance. Can Help Lower Diabetes They also increased lower SOD level, GSH, GPx, and antiapoptotic protein (Bcl-2) immunoexpression [112]. Among all the carotenoids, lycopene carries several unique benefits [ 2 ]. Lycopene is a well-known antioxidant. Lycopene was found to reduce neuropathic pain in the case of peripheral nerve injury. Some of the important daily sources of lycopene are tomatoes, soups, pasta dishes, tomato sauces and ketchup [30]. In addition to containing lycopene, theyre also considered a hydrating snack considering bell peppers are 92 percent water. -Based Complement. It is related to beta- carotene and gives some vegetables and fruits (e.g., tomatoes) a red color. Hasan T., Sultana M. Lycopene and Cardiovascular Diseases: A Review of the Literature. Multiple molecular and cellular mechanisms of action of lycopene in cancer inhibition. Furthermore, lycopene has been investigated in different doses (i.e., 0.5, 1.0, 2.0, 4.0, 8.0, 10.0 and 25 M) for the prevention of cigarette smoking-induced inflammation. Carotenoids and health in older people. Gorbatov Federal Research Center for Food Systems of Russian Academy of Sciences, Moscow 109029, Russia; ur.ay@vozeber, 13K.G. Ellis A.C., Dudenbostel T., Crowe-White K. Watermelon juice: A novel functional food to increase circulating lycopene in older adult women. 5 Reasons You Should Add Cassava Flour To 5 Reasons You Should Add Cassava Flour To Your Diet, 10 Side Effects Of Eating Lot of Tomatoes, 18 Health Benefits Of Tomatoes, How To Consume, And Recipes, 9 Health Benefits Of Dried Apricots & How Many To Eat In A Day, 15 Benefits Of L-Arginine, Dosage, And Side Effects, 13 Benefits Of Chickpeas, Nutrition, Recipes, & Side Effects, 12 Impressive Benefits Of Raw Milk For Your Skin. Improved skin, reduced wrinkles & healthy heart. It seems that this effect is via decreasing the gene fusion transmembrane protease, serine 2 (TMPRSS2): v-ets avian erythroblastosis virus E26 oncogene homolog (ERG) [91]. It should be noted that lycopene cannot be synthesized in the human body. Crowe-White K.M., Phillips T.A., Ellis A.C. Lycopene and cognitive function. Tokac M., Aydin S., Taner G., zkarde A.B., Talipinar M.Y., Doan M., Dndar H.Z., Kilic M., Baaran A.A., Baaran A.N. Lycopene administration considerably improved cognitive defects, noticeably reduced MDA levels and elevated GSH-Px activity, and remarkably reduced tau (or proteins) hyperphosphorylation at Thr231/Ser235, Ser262, and Ser396 in P301L transgenic mices brains [109] (104). Colmn-Martnez M., Martnez-Hulamo M., Valderas-Martnez P., Arranz-Martnez S., Almanza-Aguilera E., Corella D., Estruch R., Lamuela-Ravents R.M. 11 Feb. 2016, Stahl, W., and H. Sies. " The new PMC design is here! In this case-control study involving 130 prostate cancer patients and 274 hospital controls, men drinking the most As a dietary supplement, it is a potent antioxidant that is used to help prevent cancer, heart disease, and macular degeneration. They can also be used to make frozen desserts, salads, or on their own for a morning snack. In vivo studies also revealed that in mitochondria, lycopene significantly prevented DNA damage and enhanced transcription factor A level [114]. It could modify the mitochondrial membrane potential, DNA fragmentation and also affected the granularity and size of the MCF-7 cell. 1 (2007): 26-30. * Its neuroprotective effects7 also include helping to balance levels of cytokines (proteins that signal the immune system). Joshi B., Kar S.K., Yadav P.K., Yadav S., Shrestha L., Bera T.K. Lycopene supplementation (12.5 mg/kg BW) in carrageenan-induced inflammation considerably decreased edema in Swiss mice via various phlogistic compounds and immunostaining for COX-2, iNOS and NF-B. It achieved this by reversing the functioning of tumor necrosis factor, which is a substance in the human body that triggers inflammation (20). FOXO3a gene ablation reduced lycopene-caused attenuation in cell hyper-proliferation, CDK2, and CDK4 complex. Check out our. In addition, according to one study on a United States population, lycopene is the leading carotenoid in plasma and tissues [10]. This was associated with cognitive and motor impairments in rotenone-treated animals that were reversed on lycopene administration. Kwatra B. Therefore, their high dose of concomitant use should be avoided [157]. Similarly, lycopene (0.03% w/w) has been found to inhibit the LPS (0.25 mg/kg)-induced memory loss in 3-month old male C57BL/6J mice by reducing A accumulation, APP, reducing the expression of neuronal -secretase beta-site amyloid precursor protein cleaving enzyme 1 (BACE1), and improving the -secretase A disintegrin and metalloproteinase 10 (ADAM10) expressions. WebZinc also supports skin health . It may protect cells in ways other antioxidants cannot. In the US, its estimated that more than five million people are living with Alzheimers disease. Cooking breaks the cell walls of the vegetable and releases the antioxidant (4). The quick exclusion of 14CO2 indicated sufficient oxidization of the ingested lycopene. However, excess intake of foods containing lycopene may cause lycopenemia and abnormally increase birth weight in infants. The antioxidative role of lycopene was tested in the field of nephrology, also. Lycopene attenuates A1-42 secretion and its toxicity in human cell and Caenorhabditis elegans models of Alzheimer disease, Neuroscience Letters, US National Library of Medicine, National Institutes of Health. Its found in most red and pink fruits. Prevents cancer cell growth. The effects of lycopene and insulin on histological changes and the expression level of Bcl-2 family genes in the hippocampus of streptozotocin-induced diabetic rats. The adenovirus treatment with lycopene noticeably inhibited a reduction in SREBP-1c expression. Lycopene is a carotenoid (a natural red color made by plants). It's also available in natural supplement form. Sandikci M., Karagenc L., Yildiz M. Changes in the Pancreas in Experimental Diabetes and the Effect of Lycopene on These Changes: Proliferating, Apoptotic, and Estrogen Receptor Positive Cells. Mller L., Caris-Veyrat C., Lowe G., Bhm V. Lycopene and its antioxidant role in the prevention of cardiovascular diseasesA critical review. A study published in October 2012 in The American Journal of Clinical Nutrition reported that foods rich in lycopene, a plant-based pigment with antioxidant properties, can reduce the severity of sunburn and increase the moisture and elasticity of the skin. 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