Can a Radiologist See Breast Cancer from a Mammogram, Ultrasound, or MRI? Based on the type of proteins in the breast cells responsible for breast cancer, breast cancer is divided into two types:. Knowledge of possible side effects can also encourage tamoxifen users to seek medical help, if needed. (2018). Okubo T, Yokoyama Y, Kano K, Kano I. One study of 509 recurrence-free breast cancer survivors at 5 to 9 years posttreatment examined the usefulness of a comprehensive intervention that combined positive coping strategies based on CBT (e.g., calming self-talk or relaxation) with education about the disease, treatment, and potential side effects. It tends to be more aggressive than other types of breast cancer, meaning it grows and spreads faster. TMIST (Tomosynthesis Mammographic Imaging Screening Trial). The Two Sides of Dietary Antioxidants in Cancer Therapy. If you have breast cancer, your recommended treatment plan will depend on multiple factors such as: To treat breast cancer in the early stages, your care team may recommend local therapy. Clinical Oral Investigations. (2017). Global cancer patterns. That is not to say that most other supplements are safe to take there are no relevant scientific studies concerning the interactions between most supplements and aromatase inhibitors. According to the researchers, sugary foods may increase the chances of getting breast cancer and cause cancer cells to grow faster. Human epidermal growth factor receptor 2 (HER2)-positive breast. He FJ, et al. Therefore, it is important for women being treated with tamoxifen to eat a wide variety of the foods from our. Springer Science and Business Media LLC; 2020; Adewumi Akanji M, Demilade Fatinukun H, Emmanuel Rotimi D, Lawrence Afolabi B, Stephen Adeyemi O. And out of ER positive breast cancers, studies also show that around 65% of those cases also respond to progesterone. Springer Science and Business Media LLC; 2021; Maitisha G, Aimaiti M, An Z, Li X. Allicin induces cell cycle arrest and apoptosis of breast cancer cells in vitro via modulating the p53 pathway. See additional information. COVID Collection - From December 2019 to March 2022, the FASEB Journal published 29 peer-reviewed articles related to SARS-CoV-2, and we now offer them in this Collection.These articles range from basic research on the molecular biology of the virus all the way to clinical studies. We do not intend to try to solve this question. Spectroscopic study. Omega-3 fatty acid supplements add healthy fats to your diet and help lower your cholesterol levels. Research links smoking, estrogen exposure, heavy drinking, and certain dietary patterns including Western diets high in processed foods to an increased risk of breast cancer (4, 5, 6). Of the mushrooms studied, white button mushrooms have among the most powerful breast cancer chemopreventive properties. Reduction in Tamoxifen Metabolites Endoxifen and N-desmethyltamoxifen With Chronic Administration of Low Dose Cannabidiol: A CYP3A4 and CYP2D6 Drug Interaction. Talk to your doctor or nutritionist about the best diet and exercise program for you. Is there a natural cure for breast cancer? Oxford University Press (OUP); 2022; Zeng E, He W, Smedby KE, Czene K. Adjuvant Hormone TherapyRelated Hot Flashes Predict Treatment Discontinuation and Worse Breast Cancer Prognosis. (2019). One such hormone is estrogen. Special Collections. An end-to-end guide on the invasive disease, breast cancer. (2018). DOI: Jiang Y, et al. Tamoxifen is a breast cancer treatment drug that people may also take if they have ovarian tumors. This is a long-term strategy to reduce body burdens and is probably most relevant for girls and young women to reduce exposure of the developing fetus and when breastfeeding infants later on in life. Foods that are high in omega-3 fatty acids include: olive oil Clinical Breast Cancer. In addition, radiation itself reduces the level of antioxidants such as vitamin A, C, and E in tissues, which may need to be replenished. Elsevier BV; 2021; 142:112052, Costa PSd, Ramos PS, Ferreira C, Silva JL, El-Bacha T, Fialho E. Pro-Oxidant Effect of Resveratrol on Human Breast Cancer MCF-7 Cells is Associated with CK2 Inhibition. Anticancer Research USA Inc.; 2021; 42:565-579. Uyar R, Yurdakok-Dikmen B, Turgut Y, Filazi A. Diethylhexyl Phthalate and Bisphenol A Promote Vincristine and Tamoxifen Resistance in Vitro. If you have breast cancer thats estrogen receptor-positive, progesterone receptor-positive, or HER2-positive, your doctor may recommend hormone therapy or targeted therapy. Hindawi Limited; 2021; 2021:1-13. High-Estrogen Foods to Avoid 1. Flaxseed lignans enhance the cytotoxicity of chemotherapeutic agents against breast cancer cell lines MDA-MB-231 and SKBR3. Breast Cancer. Mennati A, Rostamizadeh K, Manjili HK, Fathi M, Danafar H. Co-delivery of siRNA and lycopene encapsulated hybrid lipid nanoparticles for dual silencing of insulin-like growth factor 1 receptor in MCF-7 breast cancer cell line. However, there are some foods that can protect against blood clots while not interfering with tamoxifen's effectiveness (see below). We avoid using tertiary references. A research study found that alcohol has a hormonal effect in the body, providing the nutrients needed for cancer cells to develop. Avoid foods with saturated and trans fats that can elevate LDL, including: Eating too much meat can raise your cholesterol levels. The combination of flaxseed and chemotherapy was able to stop breast cancer cells from growing. Informa UK Limited; 2021;:1-16. The following have been found to increase aromatase or estrogen or to reduce the effectiveness of aromatase inhibitors and should be limited or avoided during treatment: There is no supplement or combination of supplements that has been proven to reliably reduce the risk of ER+ breast cancer recurrence in women. See additional information. Research in a lab setting suggested that piperine has an anti-tumor effect on HER2-positive breast cancer cells. That is not to say that most other supplements are safe to take; there are no relevant scientific studies concerning the interactions between most supplements and tamoxifen. One in 5 people with breast cancer have a type called HER2-positive. Clicking on any of the foods will take you to its webpage, which contains specific information concerning that food's relationship to breast cancer (including its overall ranking, for example. Your diet may be a factor in helping to prevent and treat a variety of health conditions. Springer Science and Business Media LLC; 2021; Eid AM, Issa L, Al-kharouf O, Jaber R, Hreash F. Development of Coriandrum sativum Oil Nanoemulgel and Evaluation of Its Antimicrobial and Anticancer Activity. Journal of Food Science and Technology. Faslodex (fulvestrant) is a prescription medicine used to treat advanced breast cancer or breast cancer that has spread to other parts of the body (metastatic). These sugars may be listed as: You should also avoid simple or starchy carbohydrates, including: An imbalance of the hormone estrogen has been linked to breast cancer. Molecular Biology Reports. Researchers found that too much sugar may also worsen all types of breast cancers. There is some evidence that somewhat overweight women have a more favorable prognosis than normal weight women after tamoxifen treatment. Here are some other facts to know about breast cancer: Aside from skin cancer, breast cancer is the most common cancer in the United States. Extra-virgin olive oil met inhibitor oleocanthal-lapatinib. Learn about breast cancer causes, symptoms, tests, recovery, and prevention. Improved understanding of different types of breast cancer has led to the development of new targeted therapies that allow doctors to treat breast cancer with a more personalized approach. DOI: Vineis P, et al. Elsevier BV; 2021;:114449. Clicking on any of the foods will take you to its webpage, which contains specific information concerning that food's relationship to beast cancer (including its overall ranking, for example. The following foods or significant components have been linked specifically to increased risk of ER+/PR+ breast cancer or its recurrence: There is no supplement or combination of supplements that has been proven to reduce the risk of ER+/PR+ breast cancer recurrence in women. However, treatment can help prolong and improve quality of life in people with MBC. People With Breast Cancer Who Respond Well to Chemotherapy May Not Need Surgery, Breast Cancer: 3 Weeks of Radiation May Be Just as Effective as 6 Weeks in Early Stages, the molecular and genetic characteristics of the cancer, your overall health and treatment priorities. Effect of Tart Cherry on Aromatase Inhibitor-Induced Arthralgia (AIA) in Nonmetastatic Hormone-Positive Breast Cancer Patients: A Randomized Double-Blind Placebo-Controlled Trial. Medical treatments are necessary to remove, shrink, or slow the growth of tumors. Read on to learn more about the survival rates and treatment options for people with breast cancer, including MBC. Using tamoxifen can reduce, It has been reported that tamoxifen use in breast cancer survivors is associated with an increased risk of. Foods that are high in healthy unsaturated fats called omega-3 fatty acids are good for your overall health. Discover the signs and symptoms of breast cancer and other crucial breast cancer facts. Breast cancer statistics, 2019. Along with controlling dietary factors, pay attention to exercising that plays an equivalent role in keeping weight under control. Crous-Bou M, Du M, Gunter MJ, Setiawan VW, Schouten LJ, Shu X. LeBoff MS, Chou SH, Ratliff KA, Cook NR, Khurana B, Kim E. Goyal A, Milner GE, Cimino-Mathews A, Visvanathan K, Wolff AC, Sharma D, Zeng E, He W, Smedby KE, Czene K. Adjuvant Hormone TherapyRelated Hot Flashes Predict Treatment Discontinuation and Worse Breast Cancer Prognosis. Evidence-Based Complementary and Alternative Medicine. If your doctor gives you the OK, here's a gentle routine to try. (n.d.). Terms of Use. ER positive breast cancer is usually associated with high estrogen levels. Hesperetin and Naringenin sensitize HER2 positive cancer cells to death by serving as HER2 tyrosine kinase inhibitors. (2014). Consumption of soybean, soy foods, soy isoflavones and breast cancer incidence. Experts say advances in chemotherapy have made it less common for people to need surgery after their initial treatment for breast cancer, Researchers say three weeks of radiation treatment may be as effective as the standard four to six weeks for some people with early-stage breast. Many of the studies are done on cancer cells only or on cancer cells in mice and other animals. When you have been diagnosed with breast cancer, doctors check if you have HER2-positive or HER2-negative breast cancer. If you want a special dietary plan tailored to your needs, consider consulting a certified nutritionist. Hormone receptor positive breast cancer patients and survivors should eat a wide variety of the foods from our. (2016). Staying active can help you balance your weight. Should I get tested for the BRCA gene? Any food that increases your risk of obesity or makes you prone to inflammation triggers breast cancer, be it of any type. Serious side effects of Nerlynx include liver problems. DOI: Di Y, et al. 1996-2022 MedicineNet, Inc. All rights reserved. Some foods can enhance the effectiveness of tamoxifen treatment whereas others interfere with it. All types of meat and poultry have saturated fats. If soys estrogen-blocking action occurs in the breast, then eating soy could, in theory, reduce the risk of breast cancer because estrogen stimulates the growth and multiplication of breast and breast cancer cells. UpToDate, electronic clinical resource tool for physicians and patients that provides information on Adult Primary Care and Internal Medicine, Allergy and Immunology, Cardiovascular Medicine, Emergency Medicine, Endocrinology and Diabetes, Family Medicine, Gastroenterology and Hepatology, Hematology, Infectious Diseases, Nephrology and Hypertension, Neurology, DOI: Cruz NC, et al. Your body makes melatonin in small amounts. (2017). In 2022, the FDA expanded the use of Enhertu to treat HER2-positive and HER2-low breast cancers that have come back during or within six months of completing treatment for early-stage breast cancer. The supplements below have been found to reduce the effectiveness of tamoxifen or increase its side effects. Rose GL, Skinner TL, Keating SE, Friedrich NK, Bolam KA. What kinds of cancer treatment are there? Healthline Media does not provide medical advice, diagnosis, or treatment. We cover foods that affect aromatase or influence the treatment effects of aromatase inhibitors in Foods to eat & avoid during aromatase inhibitor treatment. Diets that are high in saturated and trans fats may make it easier for HER2-positive breast cancer cells and other types of breast cancer cells to grow. Biomedicine & Pharmacotherapy. Ovid Technologies (Wolters Kluwer Health); 2022; 149:445e-452e. Melatonin Modulation of Radiation-Induced Molecular Changes in MCF-7 Human Breast Cancer Cells, Radiomitigation by Melatonin in C57BL/6 Mice: Possible Implications as Adjuvant in Radiotherapy and Chemotherapy, Synergism of ellagic acid in combination with radiotherapy and chemotherapy for cancer treatment, Estrogen receptor inhibition mediates radiosensitization of ER-positive breast cancer models. (2016). Sugary foods include refined or simple carbohydrates or starches. It is best to obtain beneficial compounds by consuming food, if possible. (2015). Antioxidants. The American Cancer Society (ACS) reports that 99 percent of people who receive treatment for breast cancer in the earliest stages live for 5 years or longer after diagnosis. It might make sense to be tested for deficiency in vitamin D and plan for follow up to determine if your reading has reached a desirable level. Cochrane Database of Systematic Reviews. 1996-2021 MedicineNet, Inc. All rights reserved. Vegetable oils with high omega-6 content. Springer Science and Business Media LLC; 2021; Shenouda M, Copley R, Pacioles T, Lebowicz Y, Jamil M, Akpanudo S. Thompson MR, Niu J, Lei X, Nowakowska M, Wehner MR, Giordano SH. Along with a balanced diet, supplements may help you get the right nutrients. Consider eating the following citrus fruits: A research study found two specific flavonoids in citrus fruits: naringenin and hesperetin. 2015. Tamoxifen can contribute to skin problems and hair loss in some women. There is no natural cure for breast cancer. Romero SA, Young K, Hickey M, Su HI. It might make sense to be tested for deficiency in vitamin D and, if appropriate, plan for follow-up testing to determine whether your reading has reached a desirable level. (2019). DOI: Moynihan TJ. Citrus fruits contain antioxidants called flavonoids that may help slow the growth of HER2-positive cancer cells. HER2-positive breast cancers may develop or grow differently than other kinds. LIAO C, PENG S, CHEN J, CHEN P, HUANG A, LIEN J. Darling-Reed SF, Nkrumah-Elie Y, Ferguson DT, Flores-Rozas H, Mendonca P, Messeha S, Tilesi F, Lombardi A, Mazzucato A. Scientometric and Methodological Analysis of the Recent Literature on the Health-Related Effects of Tomato and Tomato Products. A high extra-virgin olive oil diet induces changes in metabolic pathways of experimental mammary tumors. Turmeric contains an antioxidant called curcumin thats been found to prevent breast cancer cells from growing. (2021). Furthermore, the adverse side effects of radiotherapy can be mitigated with antioxidant and other supplements, thereby enabling patients to endure the treatment. When inside the womb, babies are exposed to various substances, including the hormones from the mother's blood. If the test is positive, it means you have HER2-positive cancer, and if the test results are negative, you may have HER2-negative cancer, which may be either estrogen-positive or progesterone-positive cancer. Journal of Molecular Structure. However, one study reported that secretions from adipose stem cells of obese women were able to counteract the treatment effects of tamoxifen, suggesting that being overweight could contribute to tamoxifen resistance. The foods and spices listed below have been found to reduce the risk of ER+/PR+ breast cancer. Is breast cancer genetic? MDPI AG; 2021; 10:1905. Learn which 8 foods to eat to get more Estrogen. Osteoporosis International. TAILORx trial finds most women with early breast cancer do not benefit from chemotherapy. Both olive oil and flax seed contain omega-3 fatty acids and other chemicals that may help your body fight against cancer cells. Koerich S, Silva FC, Itinose AM, Bellozi PMQ, Sandrini F, Schneider SCS. Spectroscopic study, Influence of Tangeretin on Tamoxifen's Therapeutic Benefit in Mammary Cancer, Green tea polyphenol EGCG slows development of tamoxifen resistance, Omega-6 rich corn oil reduces effectiveness of tamoxifen, EV olive oil suppresses ER+ growth & increases tamoxifen effectiveness, EGCG has anti-cancer effects in tamoxifen-resistant cells. Although theres no cure for MBC, new treatment options have improved the outlook for people with this condition in recent years. Here are some other facts to know about breast cancer: Aside from skin cancer, breast cancer is the most common cancer in the United States. Journal of the National Comprehensive Cancer Network. Dietary sources and bioactivities of melatonin. The most common side effects of Faslodex include injection site pain, nausea, muscle, joint, and bone pain; headache, back pain, tiredness, pain in arms, hands, legs, or feet; hot flashes, vomiting, and others. You can learn more about how we ensure our content is accurate and current by reading our. JNCI: Journal of the National Cancer Institute. The first step in breast cancer detection and diagnosis is imaging. Side effects may be easier to tolerate if they are known to be typical. Radiomitigation by Melatonin in C57BL/6 Mice: Possible Implications as Adjuvant in Radiotherapy and Chemotherapy. SAGE Publications; 2020;:089719002097220, DellAcqua G, Richards A, Thornton MJ. Wang Y, Liu R, Chang M, Wei W, Guo Y, Jin Q. Michmerhuizen AR, Pesch AM, Schwartz R, Wilder-Romans K, Liu M, Azaria R, Agbele AT, Faromika OP, Awe OO, Amodu FR, Edaogbogun GO, Bello KA. More research is needed on specific foods for HER2-positive breast cancer. Tamoxifen (Nolvadex) is used to prevent and treat estrogen receptor-positive (ER+) breast cancer. All rights reserved. Journal of Pharmacy Practice. A 2013 medical review found that women in some parts of Asia have a lower risk of breast cancer than women in the United States. Aromatase inhibitors normally are not used to treat breast cancer in premenopausal women unless accompanied by ovarian function suppression. Investigational New Drugs. This helps to slow the cancers growth and stop it from spreading. (2013). Triple-negative breast cancer (TNBC) is a type of breast cancer. Talk to your doctor about the right exercise program for you. Vaginal Estrogen Therapy for the Genitourinary Symptoms of Menopause: Caution or Reassurance?. The following supplements generally have been found to be safe and beneficial for ER+/PR+ patients and survivors: Please consult your oncology team for advice concerning your situation and dosages. Author Ann Pietrangelo explains why her diagnosis experience felt like falling into a time warp where time seemed to speed up and slow down, all at, Healthline has strict sourcing guidelines and relies on peer-reviewed studies, academic research institutions, and medical associations. It will also vary depending on the following factors: the level of hormone receptors and/or HER2 in the tumor Foods to eat & avoid during tamoxifen treatment. These factors may cause HER2-positive breast cancer to grow and spread. MedTerms medical dictionary is the medical terminology for MedicineNet.com. That said, you may use certain complementary therapies and lifestyle changes alongside standard medical treatments to help: These complementary therapies and lifestyle may have benefits for your physical or mental health, but they will not cure cancer. (2019). Combined Network Pharmacology and Cytology Experiments to Identify Potential Anti-Breast Cancer Targets and Mechanisms of Delphinidin. Scientists continue to conduct clinical trials to develop and test treatments for breast cancer. acsjournals.onlinelibrary.wiley.com/doi/full/10.3322/caac.21583, labblog.uofmhealth.org/industry-dx/when-are-we-going-to-cure-cancer-bright-future-of-breast-cancer-research, ncbi.nlm.nih.gov/pmc/articles/PMC6691849/, ncbi.nlm.nih.gov/pmc/articles/PMC5385433/, sciencedirect.com/science/article/pii/S1319016416300196, cancer.org/cancer/breast-cancer/understanding-a-breast-cancer-diagnosis/breast-cancer-survival-rates.html, cancer.gov/news-events/press-releases/2018/tailorx-breast-cancer-chemotherapy, cancer.gov/about-cancer/treatment/clinical-trials/nci-supported/tmist, cancer.org/treatment/treatments-and-side-effects/complementary-and-alternative-medicine/complementary-and-alternative-methods-and-cancer/kinds-of-treatment.html. Consider eating more vegetables and herbs, including: These vegetables all contain phytoestrogens, or flavones, which are plant-based compounds. According to a report from the ACS, the breast cancer death rate declined by roughly 40 percent in the United States from 1989 to 2017. Survival rates for breast cancer are higher when the condition is diagnosed and treated early. The foods listed below are recommended during radiation treatment. These include: Despite weak estrogen-like action, soya and flax seeds help make tumor cells less aggressive as per some research. Elsevier BV; 2022; 99:153998. 2005-2022 Healthline Media a Red Ventures Company. High-quality academic research still reports conflicting conclusions as to whether it is safe to take certain antioxidants and other supplements in combination with radiotherapy. Hindawi Limited; 2021; 2021:1-10, Song X, Yue Z, Nie L, Zhao P, Zhu K, Wang Q. Zhang N, Xue M, Wang Q, Liang H, Yang J, Pei Z. Liang Z, Pan R, Meng X, Su J, Guo Y, Wei G, Brugnoli F, Tedeschi P, Grassilli S, Maietti A, Brandolini V, Bertagnolo V. Ethanol-based garlic extract prevents malignant evolution of non-invasive breast tumor cells induced by moderate hypoxia. Knowing the type of breast cancer you have is essential in deciding the type of treatment for youwhether you need treatments targeted at the HER2 protein, estrogen, or progesterone. Eating plenty of unprocessed soy foods may be one reason for this, but more research is needed. An animal study found that up to 58 percent of mice on a high-sugar diet developed breast cancer. Serious side effects vary depending on the condition treated. Antioxidants [Working Title]. Here's, There's currently no known cause of triple-negative breast cancer, but it is strongly associated with a family history of breast cancer and certain. We get them from veterans, first responders, office workers, athletes, seniors, parents, and everybody else. https://health.clevelandclinic.org/the-best-foods-to-eat-when-you-have-breast-cancer/. Breast cancer is the most common cancer affecting women in the United States. That means the cancer cells use estrogen to fuel growth. Another research study found that using flax seed along with chemotherapy drugs had better results than chemotherapy alone. They can help you understand the potential benefits and risks. Advancements in treatments in recent years have greatly improved survival rates and quality of life in people with breast cancer. The Journal of Nutritional Biochemistry. The effect of curcumin on breast cancer cells. Foods to eat & avoid for ER+/PR+ breast cancer, Up to two-thirds of invasive breast cancers are classified as hormone receptor positive (. This might happen because LDL helps the cancer cells make the proteins it needs to grow. This may be because sugar causes inflammation in the body. Some vegetables may help slow or stop the growth of HER2-positive cells. However, turmeric or curcumin supplements could interfere with tamoxifen treatment (see. Healthline Media does not provide medical advice, diagnosis, or treatment. Bracke ME, Depypere HT, Boterberg T, Van Marck VL, Vennekens KM, Vanluchene E, Honey, propolis or royal jelly supplements, Tamoxifen and turmeric or curcumin supplements, Coffee consumption and risk of endometrial cancer: a pooled analysis of individual participant data in the Epidemiology of Endometrial Cancer Consortium (E2C2), Supplemental Vitamin D and Incident Fractures in Midlife and Older Adults, Weight Gain after Hormone Receptor-Positive Breast Cancer, Adjuvant Hormone TherapyRelated Hot Flashes Predict Treatment Discontinuation and Worse Breast Cancer Prognosis, Alteration in glucose metabolism in the brain associated with tamoxifen treatment: Study in postmenopausal animal model, EGFR inhibition reverses epithelialmesenchymal transition, and decreases tamoxifen resistance via Snail and Twist downregulation in breast cancer cells, Metformin reverses tamoxifen resistance through the lncRNA GAS5-medicated mTOR pathway in breast cancer, Diethylhexyl Phthalate and Bisphenol A Promote Vincristine and Tamoxifen Resistance in Vitro, Insights into the Protective Effects of Thymoquinone against Toxicities Induced by Chemotherapeutic Agents, Cholesterol Depletion Modulates Drug Resistance Pathways to Sensitize Resistant Breast Cancer Cells to Tamoxifen, Baicalein resensitizes tamoxifenresistant breast cancer cells by reducing aerobic glycolysis and reversing mitochondrial dysfunction via inhibition of hypoxiainducible factor1, Dietary Supplement Use and Interactions with Tamoxifen and Aromatase Inhibitors in Breast Cancer Survivors Enrolled in Lifestyle Interventions, Time to update evidence-based guideline recommendations about concurrent tamoxifen and antidepressant use? The supplements below generally been found to be safe and beneficial for patients taking aromatase inhibitors: Please consult your oncology team for advice concerning your situation and dosages. Certain herbal supplements or other complementary therapies may interfere with cancer treatments or carry other risks. You can learn more about how we ensure our content is accurate and current by reading our. Learn about the symptoms and treatment of male breast cancer, and find out what can put you at risk for this cancer. (2017). Tamoxifen has been shown to enhance the effects of radiotherapy in ER+ breast cancer. We suggest that estrogen sensitive breast cancer patients and survivors eat a wide variety of the foods from our. Radiation Medicine and Protection. What every young women should know about breast cancer. Liu D, et al. One study suggested that melatonin helps block HER2-positive breast cancer cells from dividing. Drinking alcohol may make this worse. Breast cancer is not just one disease it comes in many variations. Below we provide a list of foods and spices that have been shown to be effective in inhibiting ER+/PR+ cell growth or proliferation.Also included are foods that incorporate significant levels of micronutrients that inhibit ER+/PR+ breast cancer. DOI: Siddique AB, et al. Breast cancer is the most common cancer affecting women in the United States. It blocks estrogen activity and therefore slows or stops cancer cell growth. (2012). However, more recent studies show that this may be incorrect. Elsevier BV; 2012; 1044:194-200. Piperine was also found to stop the HER2 gene from making HER2 proteins. Elsevier BV; 2021;:108833, Mushrooms, especially white button & related, Shellfish, especially oysters, squid & lobster, Honey, propolis or royal jelly supplements, Co-delivery of siRNA and lycopene encapsulated hybrid lipid nanoparticles for dual silencing of insulin-like growth factor 1 receptor in MCF-7 breast cancer cell line, Combined Network Pharmacology and Cytology Experiments to Identify Potential Anti-Breast Cancer Targets and Mechanisms of Delphinidin, To explore immune synergistic function of Quercetin in inhibiting breast cancer cells, Comparative study of the chemical composition and anti-proliferative activities of the aerial parts and roots of Apium graveolens L. (celery) and their biogenic nanoparticles, Myricetin inhibits breast and lung cancer cells proliferation via inhibiting MARK4, Antioxidant and anti-proliferative activity of free, conjugates and bound phenolic compounds from tomato and industrial tomato by-product, Quercetin potentiates the chemosensitivity of MCF-7 breast cancer cells to 5-fluorouracil, Allicin induces cell cycle arrest and apoptosis of breast cancer cells in vitro via modulating the p53 pathway, Development of Coriandrum sativum Oil Nanoemulgel and Evaluation of Its Antimicrobial and Anticancer Activity, Biological Functions of Diallyl Disulfide, a Garlic-Derived Natural Organic Sulfur Compound, Inhibition of fucoidan on breast cancer cells and potential enhancement of their sensitivity to chemotherapy by regulating autophagy, Transcriptome study of oleanolic acid in the inhibition of breast tumor growth based on high-throughput sequencing, Ethanol-based garlic extract prevents malignant evolution of non-invasive breast tumor cells induced by moderate hypoxia, Pro-Oxidant Effect of Resveratrol on Human Breast Cancer MCF-7 Cells is Associated with CK2 Inhibition, Allyl Isothiocyanate Induces DNA Damage and Impairs DNA Repair in Human Breast Cancer MCF-7 Cells, Diallyl Sulfide Attenuation of Carcinogenesis in Mammary Epithelial Cells through the Inhibition of ROS Formation, and DNA Strand Breaks, Scientometric and Methodological Analysis of the Recent Literature on the Health-Related Effects of Tomato and Tomato Products, Docosahexaenoic acid promotes the formation of autophagosomes in MCF-7 breast cancer cells through oxidative stress-induced growth inhibitor 1 mediated activation of AMPK/mTOR pathway. Since tamoxifen is life-saving, with proven effectiveness in preventing ER+ breast cancer and its recurrence, every effort should be made to complete treatment as prescribed. It might make sense to be tested for deficiency in vitamin D and plan for follow up to determine if your reading has reached a desirable level. Michmerhuizen A, Pesch A, Schwartz R, Wilder-Romans K, Liu M, Harold A, Mekkawy MH, Fahmy HA, Nada AS, Ali OS. Genomic studies, for the most part, have included only estrogen-receptor positive breast cancer patients. Phytoestrogens dont always mimic estrogen. Triple-negative breast cancer (TNBC) is a type of breast cancer. Targeted therapies in breast cancer: New challenges to fight against resistance. For example, with estrogen receptor-positive breast cancer, estrogen binds to specific receptors on breast cancer cells, stimulating proliferation. They may make it easier for the cancer cells to grow and spread. Springer Science and Business Media LLC; 2021; Yang K, Hou Y, Zhang Y, Liang H, Sharma A, Zheng W. Manda K, Juer D, Fischer P, Schrder A, Koenen A, Hildebrandt G. Simvastatin treatment varies the radiation response of human breast cells in 2D or 3D culture. Informa UK Limited; 2021;:1-10. Fewer treatments are available for triple-negative breast cancer. Attempting to take advantage of the apparent treatment effects of micronutrients and other dietary components by using supplements carries the risk of adverse and paradoxical effects, including promoting breast cancer growth and metastasis. Its important to note that the studies mentioned above investigated the relationship between particular compounds in foods, not the foods themselves. Avoid added sugars in foods and drinks. Radiation treatment (radiotherapy) can result in side effects such as fatigue, skin damage, and injury to the heart and lungs. To the extent that an aromatase inhibitor did decrease the production of estrogen in a premenopausal woman, the decrease would tend to stimulate the ovaries to increase androgen production, thereby neutralizing the effect of the aromatase inhibitor. Springer Science and Business Media LLC; 2021; Mawalizadeh F, Mohammadzadeh G, Khedri A, Rashidi M. Quercetin potentiates the chemosensitivity of MCF-7 breast cancer cells to 5-fluorouracil. Integrative Cancer Therapies. Whereas aromatase inhibitors block the production of estrogen. Anticancer Research USA Inc.; 2022; 36:1203-1221, Xue P, Zhang G, Zhang J, Ren L. Synergism of ellagic acid in combination with radiotherapy and chemotherapy for cancer treatment. Based on the type of proteins in the breast cells responsible for breast cancer, breast cancer is divided into two types: The HER2 protein is a type of a receptor found on the surface of the breast cells. HER2 stands for human epidermal growth factor receptor 2. (2016). One 2018 trial found that chemotherapy doesnt benefit most women with early stage breast cancer that is hormone-positive and HER2-negative. No single food or diet plan prevents breast cancer, but what you eat plays a role in how likely you are to get the disease or whether or not it comes back once youve had it. Keep your LDL cholesterol low to help prevent breast cancer and for overall good health. Over time, this might lead to more effective and personalized treatment plans. MedTerms online medical dictionary provides quick access to hard-to-spell and often misspelled medical definitions through an extensive alphabetical listing. The estrogen deprivation caused by aromatase inhibitors can also cause some of the symptoms of. Experts now know that breast cancer isnt one single disease. There is also some evidence that long-term tamoxifen use might increase the risk of macular degeneration. Triple negative breast cancer symptoms are similar to other breast cancer symptoms, but there are groups of people who may be at higher risk. Learn how and why plus other breast cancer prevention strategies. Learn about when and why it's used. DOI: Truong MD, et al. If you have breast cancer thats estrogen receptor-positive, progesterone receptor-positive, or HER2-positive, your doctor may recommend hormone therapy or targeted therapy. This is helping people with breast cancer live longer and with better quality of life on average. Nutrients. BioMed Research International. However, the only way to tell if a suspicious area is cancer is with a breast. The World Health Organization recommends that added sugars should make up less than 10 percent of your daily caloric intake. Here's how a successful editor learned to rely on, Some foods may lower your risk of breast cancer, while others may raise it. Healthline has strict sourcing guidelines and relies on peer-reviewed studies, academic research institutions, and medical associations. Not all complementary therapies are safe for people with breast cancer. 2001. Eating more soy protein rather than animal protein may also lower cholesterol and unhealthy fats in the body, which can help your body fight against breast cancer. Phytomedicine. Treatment for stage 4 or metastatic breast cancer will depend on where it has spread. Cancer Research. There are many different types of breast cancer with different causes and treatments. Some herbs and spices have anti-cancer properties. This includes surgery and sometimes radiation. Breast cancer refers to the uncontrolled growth of cells within the breast. Masoud V, et al. Mao L, et al. Oxford University Press (OUP); 2022; 6:236-236. Serious side effects of Faslodex include injection site-related nerve damage. Obesity also increases your risk of breast cancer. Apigenin induces apoptosis via extrinsic pathway, inducing p53 and inhibiting STAT3 and NFB signaling in HER2-overexpressing breast cancer cells. Khozooei S, Lettau K, Barletta F, Jost T, Rebholz S, Veerappan S. Khorasanchi A, Mukhopadhyay N, Pandey S, Nemani S, Parker GL, Urdaneta A. Alonso-Gonzlez C, Gonzlez-Abalde C, Menndez-Menndez J, Gonzlez-Gonzlez A, lvarez-Garca V, Gonzlez-Cabeza A, TRIPATHI AM, KHAN S, CHAUDHURY NK. When a beneficial micronutrient is administered at low doses by consuming food, it is likely to have subtle chemopreventive effects, whereas when the same micronutrient is administered at a high dose in a supplement, it is more likely to have pharmacological effects, with mostly unknown results. Breast cancer is the most common form of cancer affecting women and is also now the most commonly diagnosed cancer worldwide. We avoid using tertiary references. DOI: Haytowitz DB, et al. Health & Diet DOI: Denmark-Wahnefried W, et al. The growth of ER+ (i.e., estrogen sensitive) breast cancer is promoted by estrogen. A 2020 article in the Journal of Clinical Oncology shows that 79 to 84 percent of breast cancers test positive for estrogen receptors. According to a 2012 study, obesity and excess weight may lead to a worse prognosis. Instead of a focus on total fat, Approximately 20 to 30 percent of all cancers may be related to diet, physical activity, and other similar modifiable risk factors. What Is Neoadjuvant Chemotherapy for Breast Cancer? These women may benefit from surgery and hormone therapy instead. 2005-2022 Healthline Media a Red Ventures Company. This causes the HER2-positive cancer cells to shrink or die. Fisusi FA, et al. It might make sense to be tested for deficiency in vitamin D and plan for follow up to determine if your reading has reached a desirable level. Zoladex (goserelin acetate) implant is a GnRH agonist used to treat advanced breast cancer, prostate cancer, endometriosis, and endometrial thinning. Adjuvant Hormone TherapyRelated Hot Flashes Predict Treatment Discontinuation and Worse Breast Cancer Prognosis, Obesity Impact on Managing Aromatase Inhibitors Side Effects in Breast Cancer Patients, 86P Change in dietary habits does not affect body composition in early breast cancer patients treated with aromatase inhibitor, Risk of Cardiovascular Disease in Women With and Without Breast Cancer: The Pathways Heart Study, Gingerol/letrozole-loaded mesoporous silica nanoparticles for breast cancer therapy: In-silico and in-vitro studies, Gynecologic Symptoms among Hormone Receptor-Positive Breast Cancer Patients on Oral Endocrine Therapy: A Cross-Sectional Study, Abstract P5-18-12: Cardioprotective effects of walnuts against aromatase inhibitor: Pilot study in a zebrafish model, Aromatase InhibitorInduced Carpal Tunnel Syndrome and Stenosing Tenosynovitis: A Systematic Review, Sulindac Improves Stiffness and Quality of Life in Women Taking Aromatase Inhibitors for Breast Cancer, Dietary Supplement Use and Interactions with Tamoxifen and Aromatase Inhibitors in Breast Cancer Survivors Enrolled in Lifestyle Interventions, The effects of exercise on the bone health of people with cancer: a systematic review and meta-analysis, Effect of Tart Cherry on Aromatase Inhibitor-Induced Arthralgia (AIA) in Nonmetastatic Hormone-Positive Breast Cancer Patients: A Randomized Double-Blind Placebo-Controlled Trial, Association of Endocrine Therapy and Dementia in Women with Breast Cancer, Vitamin D Compounds PRI-2191 and PRI-2205 Enhance Anastrozole Activity in Human Breast Cancer Models, Effects of obesity on breast aromatase expression and systemic metabo-inflammation in women with BRCA1 or BRCA2 mutations, From Theory to Practice: Bone Health in Women with Early Breast Cancer Treated with Aromatase Inhibitors, Off-treatment bone mineral density changes in postmenopausal women receiving anastrozole for 5 years: 7-year results from the IBIS-II prevention trial, The Potential Role of Nutraceuticals as an Adjuvant in Breast Cancer Patients to Prevent Hair Loss Induced by Endocrine Therapy, Impact of endocrine therapy (hormone therapy) on BC prognosis, Aromatase inhibitor treatment and weight gain, Treatment with Femara after tamoxifen can worsen cholesterol profile, Side effects of anti-estrogens can indicate treatment is working. Melatonin supplementation for preventing cancer-related fatigue in patients receiving radiotherapy for early-stage breast cancer: A double-blind placebo-controlled phase III trial. Revisiting the Anticancer DrugFood Interactions. In addition, this webpage lists foods, spices and supplements that appear to be risky because they (or significant The food lists, which are updated continually as new research becomes available, have been developed based solely on the results of published academic studies. 90-95% were attributable to environmental and lifestyle factors such as, Red meat and chicken with skin (increases your. Clinical applicability of natural products for prevention and treatment of oral mucositis: a systematic review and meta-analysis. The cancer cells will be checked for certain receptors, such as estrogen, progesterone, and HER2 (a growth-promoting protein found on the outside of breast cells). Our website services, content, and products are for informational purposes only. Aromasin should be taken after a meal to avoid nausea or indigestion. The following supplements generally have been found to be safe and beneficial for those being treated with tamoxifen: Please consult your oncology team for advice concerning your situation and dosages. Wheat & Other Grains In 2018, Scripps Research Institute scientists published a study showing that two common estrogen-mimicking compounds in foods may actually shut down the benefits of a popular drug combination used to treat metastatic, estrogen receptor-positive breast cancer in postmenopausal women. Impact of metformin on the therapeutic effect of radiotherapy. Decreasing the production of estrogen with an aromatase inhibitor is designed to reduce recurrence. We love reading positive stories about the impact our products have on peoples everyday lives. Pan S, Yuan C, Tagmount A, et al. Martinez JA, Wertheim BC, Roe DJ, Chalasani P, Cohen J, Baer L. Harrigan M, McGowan C, Hood A, Ferrucci LM, Nguyen T, Cartmel B. Molecular Biology Reports. ER-dependent estrogenic activity of parabens assessed by proliferation of human breast cancer MCF-7 cells and expression of ERalpha and PR. A number of foods or their component molecules have been shown to help obtain relief from these adverse effects without lessening the cytotoxic impact of radiation on breast cancer cells. Related Resources - What Foods To Avoid If You Have Estrogen Positive Breast Cancer. Scientists are also studying ways to improve breast cancer screening and diagnosis to detect breast cancer in the earliest stage possible. Foods to eat if you have HER2-positive breast cancer, Foods to avoid if you have HER2-positive breast cancer, Lifestyle tips for HER2-positive breast cancer, cancer.org/cancer/cancer-causes/diet-physical-activity/diet-and-physical-activity.html, ars.usda.gov/ARSUserFiles/80400525/Articles/AICR03_VegFlav.pdf, fasebj.org/doi/abs/10.1096/fasebj.31.1_supplement.646.62, mayoclinic.org/breast-cancer/expert-answers/faq-20058066, Knowledge Is Power with Early Breast Cancer, Yes, You Can! If the cancer progresses despite tamoxifen treatment, it is more likely to recur as ER- disease, which is normally more aggressive than ER+ breast cancer. Aromatase InhibitorInduced Carpal Tunnel Syndrome and Stenosing Tenosynovitis: A Systematic Review. How are clinical trials helping to improve treatments? Anwar S, Khan S, Anjum F, Shamsi A, Khan P, Fatima H. Perea-Domnguez XP, Mendoza-Espinoza JA, Solano Gonzlez JM, Leyva-Morales JB, Espinosa-Alonso LG, Valdez-Morales M. Antioxidant and anti-proliferative activity of free, conjugates and bound phenolic compounds from tomato and industrial tomato by-product. Natural cures for breast cancer treatment. Shareef M, et al. MDPI AG; 2022; 11:2149. The supplements below have been found specifically to increase estrogen or aromatase, reduce the effectiveness of aromatase inhibitors, or increase their side effects, and should be avoided during treatment. Qiu D, Yan X, Xiao X, Zhang G, Wang Y, Cao J. Ahmed SST, Fahim JR, Youssif KA, Amin MN, Abdel-Aziz HM, Khadra IA. To varying degrees, women taking aromatase inhibitors experience menopausal symptoms such as increases in joint disorders, bone fractures, and vaginal/urogenital atrophy, in addition to weight gain and higher. What foods to avoid if you have estrogen-positive breast cancer? This means that it stops the cells from growing and causes them to die. Tamoxifen is associated with higher risk of certain gynecological side effects, including. There is a HER2 gene that controls the production of HER2. (2021). tomosynthesis mammographic imaging screening trial. When breast cancer spreads to distant parts of the body, its known as metastatic breast cancer (MBC) and is harder to treat. Aromatase inhibitors include Arimidex (. The following foods (or major components) have been shown to help reduce some of the side effects of aromatase inhibitors: Moderate to vigorous physical activity, particularly. This natural chemical may also have anti-cancer properties. When there is a defect in this gene, it makes more than the required copies of HER2. Not all breast cancer is linked to estrogen, but estrogen receptor positive (ER+) cancers are the most common type of breast cancer. This is linked with a higher risk for estrogen receptor-positive breast cancer. Elevated tumor LDLR expression accelerates LDL cholesterol-mediated breast cancer growth in mouse models of hyperlipidemia. (2013). In a lab setting, the flavonoids helped stop HER2-positive cancer cells from growing. Our experts continually monitor the health and wellness space, and we update our articles when new information becomes available. Consider adding the following soy foods to your daily diet: Grapes and grape seeds contain a number of healthy compounds that may help treat HER2-positive breast cancer. Lima ICGdS, de Ftima Souto Maior L, Gueiros LAM, Leo JC, Higino JS, Carvalho AAT. In addition, There is also some evidence that exposure to bisphenol A (. Nutrition and Cancer. International Journal of Biological Macromolecules. Our doctors define difficult medical language in easy-to-understand explanations of over 19,000 medical terms. Fatty fish. Dr. Alyssa Walton answers questions about cancer-related pain and how to manage it. Also, a balanced diet (including adequate amounts of fruits, vegetables and cereals) will help to avoid excessive exposure from a single source. Excess of HER2 results in overgrowth of the abnormal breast cells, giving rise to HER2-positive cancer. The following should be limited during aromatase inhibitor treatment since high consumption could contribute to bone loss: A 2021 study reported that aromatase inhibitor-induced bone loss appears to be partially reversible after treatment is completed. Fawcett N. (2017). A 2012 lab study suggested that a phytoestrogen called apigenin helped block the growth of HER2-postive breast cancer cells. Research also suggests that cholesterol-lowering drugs could result in less radiation resistance among hormone receptor positive and inflammatory breast cancer If you have breast cancer, you may be wondering if it's safe to practice yoga. These are known as triple-negative breast cancers. Results may differ when investigating dietary intake in people who are at risk for breast cancer. The outlook for people with breast cancer might have improved further since then, with more recent advances in diagnosis and treatment tools. Eating a well-balanced diet, getting enough sleep, and practicing other healthy habits will help support your overall health. Please note that these foods are not a replacement for your regular cancer treatment. MDPI AG; 2020; 12:3537, impact of endocrine therapy on breast cancer prognosis, Foods that increase or reduce aromatase activity, Supplemental Vitamin D and Incident Fractures in Midlife and Older Adults. For the same reason, some women benefit from taking Aromasin at night. Given that its the highest food by far, this one should be prioritized. Turmeric consumed as food is likely to be beneficial. LeBoff MS, Chou SH, Ratliff KA, Cook NR, Khurana B, Kim E. Cathcart-Rake EJ, Ruddy KJ. (2016). In 2019 the FDA approved Enhertu (fam-trastuzumab-deruxtecan-nxki) to treat adults with certain types of HER2-positive breast cancer. Breast cancer typically eventually develops resistance to tamoxifen. Cancer prevention and treatment guidelines commonly recommend a low-fat diet, but research results on this connection have been inconsistent. The food lists, which are updated continually as new research becomes available, have been developed based solely on the results of published academic studies. While we believe CBD can support wellness in many ways, you have to understand this is still a young industry. Impact of combining vitamin C with radiation therapy in human breast cancer: does it matter? Weight management and its role in breast cancer rehabilitation. Last medically reviewed on January 28, 2019. Foods that are high in omega-3 fatty acids include: An animal study suggested that extra virgin olive oil helped to slow the spread of HER2-positive breast cancer cells. The hormone estrogen, for example, may actually reduce acne. Breast cancer is one of the most common cancers. According to the ACS, the 5-year survival rate for people with MBC is 28 percent. Our experts continually monitor the health and wellness space, and we update our articles when new information becomes available. Breast cancer is highly treatable in the early stages of the condition, before it spreads to other parts of the body. People with MBC may go through periods of time when the condition is well controlled with treatment. For example, the WINS trial linked a low-fat diet to lower recurrence and greater survival rates, but these benefits were much more significant in women with ER-negative breast cancer. All rights reserved. Some foods may slow the growth of HER2-positive breast cancer by reducing how much HER2 protein is made. This means that the cancer cells have a gene that makes HER2 protein. Antioxidant supplementation and breast cancer prognosis in postmenopausal women undergoing chemotherapy and radiation therapy, Radiotherapy can convert surviving cancer cells into stem cells, Resveratrol sensitizes ER+/PR+ cells to radiation treatment, Enterolactone increases radiation-induced breast cancer cell death, Calorie restriction heightens effects of radiotherapy in TN tumors, Metformin may increase the effectiveness of radiation treatment. These healthy fats can lower and balance cholesterol levels and help treat HER2-positive breast cancer and other types of breast cancer. Plastic & Reconstructive Surgery. Almost 25 percent of people newly diagnosed with cancer have breast cancer. Chemical Research in Toxicology. Acupuncture and ginger may help relieve nausea and vomiting related to cancer treatments such as chemotherapy. This is thought to be because resveratrol can balance natural estrogen hormones in the body. Journal of Pharmaceutical and Biomedical Analysis. Black pepper contains an active compound called piperine. Here are a few foods to eat and avoid. Patients whose tumors are estrogen receptor positive are more likely to benefit.-Ductal Carcinoma in Situ (DCIS): In women with DCIS, following breast surgery and radiation, to reduce the risk of invasive breast cancer.-Reduction in Breast Cancer Incidence in High Risk Women: To reduce the incidence of breast cancer in women at high risk. American Chemical Society (ACS); 2022; Farooq J, Sultana R, Taj T, Asdaq SMB, Alsalman AJ, Mohaini MA, HENRIQUES PALMA GB, KAUR M. Cholesterol Depletion Modulates Drug Resistance Pathways to Sensitize Resistant Breast Cancer Cells to Tamoxifen. Breast cancer isn't just a woman's disease. Alcohol enhances estrogen-responsive breast cancer neovascularization. DOI: Diet and physical activity: What's the cancer connection? DOI: Mackert JD, et al. Learning more about different types of breast cancer has allowed scientists to develop new diagnostic tools and treatments. A lump in the breast is almost always cancer. Sugary foods can increase your risk of health problems, including some cancers. IntechOpen; 2020; Bracone F, De Curtis A, Di Castelnuovo A, Pilu R, Boccardi M, Cilla S. Jung AY, Cai X, Thoene K, Obi N, Jaskulski S, Behrens S, The Self-Administered Use of Complementary and Alternative Medicine (CAM) Supplements and Antioxidants in Cancer Therapy and the Critical Role of Nrf-2A Systematic Review, Fisetin induces DNA double-strand break and interferes with the repair of radiation-induced damage to radiosensitize triple negative breast cancer cells. Journal of the National Comprehensive Cancer Network. It is involved in the normal growth of the breast cells. Drug combinations in breast cancer therapy. Chandrika BB, et al. While test-tube studies have shown vitamin D to have a positive effect on the immune response of human cells, researchers are yet to replicate these findings in controlled human trials. Laini L, Bonalumi A, Bosio S, Villa N, Amoroso V, Lorini L. Greenlee H, Iribarren C, Rana JS, Cheng R, Nguyen-Huynh M, Rillamas-Sun E. Akbarzadeh I, Poor AS, Khodarahmi M, Abdihaji M, Moammeri A, Jafari S. Moskalewicz A, Di Tomaso A, Kachura JJ, Scime S, Nisenbaum R, Lee R, Hilakivi-Clarke L, Da Silva JL, Blaes A, Hoeppner L. Abstract P5-18-12: Cardioprotective effects of walnuts against aromatase inhibitor: Pilot study in a zebrafish model. DOI: Can diet help HER2-positive breast cancer? Other foods may block cancer cells from getting nutrition or make them more sensitive to drug treatment. Radiosensitizing Effect of Bromelain Using Tumor Mice Model via Ki-67 and PARP-1 Inhibition. One of the primary factors in determining the type of breast cancer is the sensitivity of the tumor cells to estrogen. It tends to be more aggressive than other types of breast cancer, meaning it grows and spreads faster. Annals of Translational Medicine. Supplements should be used if medically necessary or to make up for deficiencies that are difficult to correct through diet. Discover the types of treatments such as surgery and drug therapies as well as the survival rate for breast cancer. Arimidex and Femara can be taken with or without food. LIVESTRONG.COM offers diet, nutrition and fitness tips for a healthier lifestyle. Animal products also lower melatonin levels in the body. Pink Lady apple peel inhibits ER+/PR+ breast cancer growth, Estrogen in chicken & beef may contribute to estrogen-sensitive BC, Italian women with high vegetable consumption have lower BC risk, EV olive oil suppresses ER+ growth & increases tamoxifen effectiveness, Cucumber has anti-cancer activities in ER+, HER2+ and TN cells, Angelica sinensis (dong quai) supplements. If a breast tumor is hormone-sensitive or estrogen receptor-positive, it means there are specific estrogen receptors on the tumor cells, and when estrogen binds with these receptors, it transfers a When a beneficial micronutrient is administered at low doses by consuming food, it is likely to have subtle chemopreventive effects, whereas when the same micronutrient is administered at a high dose in a supplement, it is more likely to have pharmacological effects, with mostly unknown results. MDPI AG; 2020; 12:3537, Maciek-Jurczyk M, Maliszewska M, Poycka J, Rwnicka-Zubik J, Gra A, Sukowska A. Tamoxifen and curcumin binding to serum albumin. 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